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| Verfasst von: | Minckwitz, Gunter von [VerfasserIn]  |
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| | Kühn, W. [VerfasserIn] |
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| | Kaufmann, Manfred [VerfasserIn] |
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| | Feichter, Georg E. [VerfasserIn] |
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| | Heep, Josef [VerfasserIn] |
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| | Schmid, Hans [VerfasserIn] |
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| | Bastert, Gunther [VerfasserIn] |
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| Titel: | Prognostic importance of DNA-ploidy and S-phase fraction in endometrial cancer |
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| Verf.angabe: | G. von Minckwitz, W. Kühn, M. Kaufmann, G.E. Feichter, J. Heep, H. Schmid, G. Bastert |
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| E-Jahr: | 1994 |
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| Jahr: | July 01, 1994 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 14.02.2024 |
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| Titel Quelle: | Enthalten in: International journal of gynecological cancer |
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| Ort Quelle: | London : BMJ Publishing Group Ltd, 1991 |
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| Jahr Quelle: | 1994 |
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| Band/Heft Quelle: | 4(1994), 4, Seite 250-256 |
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| ISSN Quelle: | 1525-1438 |
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| Abstract: | On fresh frozen tumor tissue from 161 patients with endometrial cancer DNA-ploidy and S-phase fraction were measured in a prospective study to evaluate their prognostic and predictive value. All FIGO stage I or II patients had surgery and were included in an adjuvant trial comparing tamoxifen 30 mg p.o. versus medroxyprogesterone acetate 500 mg p.o. for 2 years versus no therapy. Diploid (DNA index (DI) ⩽ 1.1) tumors were found in 75%. S-phase fraction was elevated (>5%) in 46 (30%) of the patients. Significant correlations of DNA-ploidy and S-phase fraction were found with classical parameters such as stage, grade, histologic type and estrogen and progesterone receptor status. Patients with FIGO stage I aneuploid tumors showed significantly shorter disease-free interval (DFS) and overall survival (OAS). Recurrences and deaths occurred more often in tumors with raised S-phase fraction. In these early stages clinical outcome was worst if both factors were unfavorable. In multivariate analysis of stage I tumors DNA-ploidy and S-phase fraction were independent of grade, type and estrogen receptor status. Patients whose tumors had elevated S-phase fractions (>5%) gained more benefit from endocrine treatment than patients with low S-phase fractions. Patients with diploid and aneuploid tumors had prolonged DFS and improved OAS, if they had received adjuvant hormonal therapy. In endometrial cancer, DNA-ploidy and S-phase fraction are objective and reliable prognostic and predictive parameters which should be integrated into the clinical management. |
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| DOI: | doi:10.1046/j.1525-1438.1994.04040250.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1046/j.1525-1438.1994.04040250.x |
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| | Volltext: https://ijgc.bmj.com/content/4/4/250 |
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| | DOI: https://doi.org/10.1046/j.1525-1438.1994.04040250.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | DNA-ploidy |
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| | endometrial cancer |
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| | predictive value |
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| | prognosis |
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| | S-phase fraction |
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| K10plus-PPN: | 1880744260 |
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| Verknüpfungen: | → Zeitschrift |
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Prognostic importance of DNA-ploidy and S-phase fraction in endometrial cancer / Minckwitz, Gunter von [VerfasserIn]; July 01, 1994 (Online-Ressource)
