| |  Online-Ressource |
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| Verfasst von: | Grigoryan, Ani [VerfasserIn]  |
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| | Pospiech, Johannes [VerfasserIn] |
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| | Krämer, Stephen [VerfasserIn] |
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| | Lipka, Daniel [VerfasserIn] |
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| | Liehr, Thomas [VerfasserIn] |
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| | Geiger, Hartmut [VerfasserIn] |
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| | Kimura, Hiroshi [VerfasserIn] |
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| | Medhanie Assmelash Mulaw [VerfasserIn] |
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| | Florian, Maria Carolina [VerfasserIn] |
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| Titel: | Attrition of X chromosome inactivation in aged hematopoietic stem cells |
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| Verf.angabe: | Ani Grigoryan, Johannes Pospiech, Stephen Krämer, Daniel Lipka, Thomas Liehr, Hartmut Geiger, Hiroshi Kimura, Medhanie A. Mulaw, and Maria Carolina Florian |
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| E-Jahr: | 2021 |
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| Jahr: | 13 April 2021 |
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| Umfang: | 9 S. |
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| Titel Quelle: | Enthalten in: Stem cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2013 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 16(2021), 4 vom: Apr., Seite 708-716 |
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| ISSN Quelle: | 2213-6711 |
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| Abstract: | During X chromosome inactivation (XCI), the inactive X chromosome (Xi) is recruited to the nuclear lamina at the nuclear periphery. Beside X chromosome reactivation resulting in a highly penetrant aging-like hematopoietic malignancy, little is known about XCI in aged hematopoietic stem cells (HSCs). Here, we demonstrate that LaminA/C defines a distinct repressive nuclear compartment for XCI in young HSCs, and its reduction in aged HSCs correlates with an impairment in the overall control of XCI. Integrated omics analyses reveal higher variation in gene expression, global hypomethylation, and significantly increased chromatin accessibility on the X chromosome (Chr X) in aged HSCs. In summary, our data support the role of LaminA/C in the establishment of a special repressive compartment for XCI in HSCs, which is impaired upon aging. |
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| DOI: | doi:10.1016/j.stemcr.2021.03.007 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.stemcr.2021.03.007 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2213671121001375 |
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| | DOI: https://doi.org/10.1016/j.stemcr.2021.03.007 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | aging |
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| | ATACseq |
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| | chromatin accessibility |
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| | chromatin architecture |
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| | hematopoietic stem cell |
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| | HSC |
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| | LaminA/C |
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| | scRNAseq |
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| | X chromosome inactivation |
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| K10plus-PPN: | 1760200182 |
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| Verknüpfungen: | → Zeitschrift |
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Attrition of X chromosome inactivation in aged hematopoietic stem cells / Grigoryan, Ani [VerfasserIn]; 13 April 2021 (Online-Ressource)
