| |  Online-Ressource |
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| Verfasst von: | Zopfs, Malte [VerfasserIn]  |
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| | Jindrová, Miroslava [VerfasserIn] |
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| | Gurevitch, Guy [VerfasserIn] |
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| | Keynan, Jackob N. [VerfasserIn] |
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| | Hendler, Talma [VerfasserIn] |
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| | Baumeister, Sarah [VerfasserIn] |
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| | Aggensteiner, Pascal [VerfasserIn] |
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| | Cornelisse, Sven [VerfasserIn] |
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| | Brandeis, Daniel [VerfasserIn] |
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| | Schmahl, Christian [VerfasserIn] |
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| | Paret, Christian [VerfasserIn] |
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| Titel: | Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation |
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| Titelzusatz: | proof-of-concept in borderline personality disorder: original article |
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| Verf.angabe: | Malte Zopfs, Miroslava Jindrová, Guy Gurevitch, Jackob N. Keynan, Talma Hendler, Sarah Baumeister, Pascal-M. Aggensteiner, Sven Cornelisse, Daniel Brandeis, Christian Schmahl and Christian Paret |
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| E-Jahr: | 2023 |
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| Jahr: | 22 December 2023 |
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| Umfang: | 10 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 15.02.2024 |
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| Titel Quelle: | Enthalten in: Psychological medicine |
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| Ort Quelle: | Cambridge : Cambridge University Press, 1970 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 54(2024), 8, Seite 1651-1660 |
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| ISSN Quelle: | 1469-8978 |
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| Abstract: | Background: The modulation of brain circuits of emotion is a promising pathway to treat borderline personality disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the amygdala-related electrical fingerprint (Amyg-EFP) in BPD are presented: one study addressing the deep-brain correlates of Amyg-EFP, and a second study investigating neurofeedback (NF) as a means to improve brain self-regulation.MethodsStudy 1 combined electroencephalography (EEG) and simultaneous functional magnetic resonance imaging to investigate the replicability of Amyg-EFP-related brain activation found in the reference dataset (N = 24 healthy subjects, 8 female; re-analysis of published data) in the replication dataset (N = 16 female individuals with BPD). In the replication dataset, we additionally explored how the Amyg-EFP would map to neural circuits defined by the research domain criteria. Study 2 investigated a 10-session Amyg-EFP NF training in parallel to a 12-weeks residential dialectical behavior therapy (DBT) program. Fifteen patients with BPD completed the training, N = 15 matched patients served as DBT-only controls.ResultsStudy 1 replicated previous findings and showed significant amygdala blood oxygenation level dependent activation in a whole-brain regression analysis with the Amyg-EFP. Neurocircuitry activation (negative affect, salience, and cognitive control) was correlated with the Amyg-EFP signal. Study 2 showed Amyg-EFP modulation with NF training, but patients received reversed feedback for technical reasons, which limited interpretation of results.ConclusionsRecorded via scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Administering Amyg-EFP NF in addition to standardized BPD treatment was shown to be feasible. Clinical utility remains to be investigated. |
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| DOI: | doi:10.1017/S0033291723003549 |
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| URL: | Volltext: https://doi.org/10.1017/S0033291723003549 |
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| | Volltext: https://www.cambridge.org/core/journals/psychological-medicine/article/amygdalarelated-electrical-fingerprint-is-modulat ... |
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| | DOI: https://doi.org/10.1017/S0033291723003549 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Affective Lability Scale |
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| | amygdala |
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| | amygdala-related electrical fingerprint |
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| | Beck's Depression Inventory |
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| | blood oxygenation level dependent |
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| | borderline personality disorder |
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| | brain imaging data structure |
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| | default-mode network |
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| | dialectical behavior therapy |
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| | dorsal anterior cingulate cortex |
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| | dorsolateral prefrontal cortex |
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| | EEG |
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| | electro-oculogram |
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| | electroencephalography |
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| | emotion regulation |
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| | fMRI |
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| | functional magnetic resonance imaging |
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| | general linear model |
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| | interquartile range |
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| | neurofeedback |
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| | neuroimaging |
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| | personal effect size |
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| | post-traumatic stress disorder |
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| | psychopathology |
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| | silver/silver chloride |
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| | State-Trait Anxiety Inventory |
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| | Toronto alexithymia Scale |
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| K10plus-PPN: | 1880829096 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation / Zopfs, Malte [VerfasserIn]; 22 December 2023 (Online-Ressource)
