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| Verfasst von: | Wichert, Katharina [VerfasserIn]  |
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| | Hoppe, Reiner [VerfasserIn] |
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| | Ickstadt, Katja [VerfasserIn] |
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| | Behrens, Thomas [VerfasserIn] |
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| | Winter, Stefan [VerfasserIn] |
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| | Herold, Robert [VerfasserIn] |
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| | Terschüren, Claudia [VerfasserIn] |
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| | Lo, Wing-Yee [VerfasserIn] |
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| | Guénel, Pascal [VerfasserIn] |
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| | Truong, Thérèse [VerfasserIn] |
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| | Bolla, Manjeet K. [VerfasserIn] |
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| | Wang, Qin [VerfasserIn] |
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| | Dennis, Joe [VerfasserIn] |
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| | Michailidou, Kyriaki [VerfasserIn] |
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| | Lush, Michael [VerfasserIn] |
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| | Andrulis, Irene L. [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| | Chang-Claude, Jenny [VerfasserIn] |
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| | Cox, Angela [VerfasserIn] |
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| | Cross, Simon S. [VerfasserIn] |
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| | Czene, Kamila [VerfasserIn] |
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| | Eriksson, Mikael [VerfasserIn] |
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| | Figueroa, Jonine D. [VerfasserIn] |
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| | García-Closas, Montserrat [VerfasserIn] |
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| | Goldberg, Mark S. [VerfasserIn] |
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| | Hamann, Ute [VerfasserIn] |
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| | He, Wei [VerfasserIn] |
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| | Holleczek, Bernd [VerfasserIn] |
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| | Hopper, John L. [VerfasserIn] |
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| | Jakubowska, Anna [VerfasserIn] |
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| | Ko, Yon-Dschun [VerfasserIn] |
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| | Lubiński, Jan [VerfasserIn] |
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| | Mulligan, Anna Marie [VerfasserIn] |
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| | Obi, Nadia [VerfasserIn] |
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| | Rhenius, Valerie [VerfasserIn] |
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| | Shah, Mitul [VerfasserIn] |
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| | Shu, Xiao-Ou [VerfasserIn] |
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| | Simard, Jacques [VerfasserIn] |
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| | Southey, Melissa C. [VerfasserIn] |
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| | Zheng, Wei [VerfasserIn] |
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| | Dunning, Alison M. [VerfasserIn] |
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| | Pharoah, Paul D. P. [VerfasserIn] |
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| | Hall, Per [VerfasserIn] |
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| | Easton, Douglas F. [VerfasserIn] |
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| | Brüning, Thomas [VerfasserIn] |
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| | Brauch, Hiltrud [VerfasserIn] |
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| | Harth, Volker [VerfasserIn] |
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| | Rabstein, Sylvia [VerfasserIn] |
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| Titel: | Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer |
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| Verf.angabe: | Katharina Wichert, Reiner Hoppe, Katja Ickstadt, Thomas Behrens, Stefan Winter, Robert Herold, Claudia Terschüren, Wing-Yee Lo, Pascal Guénel, Thérèse Truong, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Irene L. Andrulis, Hermann Brenner, Jenny Chang-Claude, Angela Cox, Simon S. Cross, Kamila Czene, Mikael Eriksson, Jonine D. Figueroa, Montserrat García-Closas, Mark S. Goldberg, Ute Hamann, Wei He, Bernd Holleczek, John L. Hopper, Anna Jakubowska, Yon-Dschun Ko, Jan Lubiński, Anna Marie Mulligan, Nadia Obi, Valerie Rhenius, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Melissa C. Southey, Wei Zheng, Alison M. Dunning, Paul D.P. Pharoah, Per Hall, Douglas F. Easton, Thomas Brüning, Hiltrud Brauch, Volker Harth, Sylvia Rabstein |
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| E-Jahr: | 2023 |
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| Jahr: | 03 October 2023 |
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| Umfang: | 16 S. |
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| Fussnoten: | Gesehen am 16.02.2024 |
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| Titel Quelle: | Enthalten in: European journal of epidemiology |
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| Ort Quelle: | [Cham] : Springer Nature Switzerland AG, 1985 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 38(2023), 10, Seite 1053-1068 |
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| ISSN Quelle: | 1573-7284 |
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| Abstract: | Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We applied a large-scale molecular epidemiology approach to shed light on the putative role of melatonin in breast cancer. We investigated associations between breast-cancer risk and polymorphisms at genes of melatonin biosynthesis/signaling using a study population of 44,405 women from the Breast Cancer Association Consortium (22,992 cases, 21,413 population-based controls). Genotype data of 97 candidate single nucleotide polymorphisms (SNPs) at 18 defined gene regions were investigated for breast-cancer risk effects. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (CI) by logistic regression for the main-effect analysis as well as stratified analyses by estrogen- and progesterone-receptor (ER, PR) status. SNP-SNP interactions were analyzed via a two-step procedure based on logic regression. The Bayesian false-discovery probability (BFDP) was used for all analyses to account for multiple testing. Noteworthy associations (BFDP < 0.8) included 10 linked SNPs in tryptophan hydroxylase 2 (TPH2) (e.g. rs1386492: OR = 1.07, 95% CI 1.02-1.12), and a SNP in the mitogen-activated protein kinase 8 (MAPK8) (rs10857561: OR = 1.11, 95% CI 1.04-1.18). The SNP-SNP interaction analysis revealed noteworthy interaction terms with TPH2- and MAPK-related SNPs (e.g. rs1386483R ∧ rs1473473D ∧ rs3729931D: OR = 1.20, 95% CI 1.09-1.32). In line with the light-at-night hypothesis that links shift work with elevated breast-cancer risks our results point to SNPs in TPH2 and MAPK-genes that may impact the intricate network of circadian regulation. |
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| DOI: | doi:10.1007/s10654-023-01048-7 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s10654-023-01048-7 |
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| | DOI: https://doi.org/10.1007/s10654-023-01048-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Circadian rhythm |
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| | MAPK8 |
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| | Serotonin biosynthesis |
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| | Shift work |
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| | TPH2 |
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| K10plus-PPN: | 1880997339 |
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| Verknüpfungen: | → Zeitschrift |
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Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer / Wichert, Katharina [VerfasserIn]; 03 October 2023 (Online-Ressource)
