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Status: Bibliographieeintrag

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Verfasst von:Farhat, Joviana [VerfasserIn]   i
 Alzyoud, Lara [VerfasserIn]   i
 AlWahsh, Mohammad [VerfasserIn]   i
 Al-Omari, Basem [VerfasserIn]   i
Titel:Structure-activity relationship of benzofuran derivatives with potential anticancer activity
Verf.angabe:Joviana Farhat, Lara Alzyoud, Mohammad Alwahsh and Basem Al-Omari
E-Jahr:2022
Jahr:28 April 2022
Umfang:22 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 19.02.2024
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2022
Band/Heft Quelle:14(2022), 9, Artikel-ID 2196, Seite 1-22
ISSN Quelle:2072-6694
Abstract:Benzofuran is a heterocyclic compound found naturally in plants and it can also be obtained through synthetic reactions. Multiple physicochemical characteristics and versatile features distinguish benzofuran, and its chemical structure is composed of fused benzene and furan rings. Benzofuran derivatives are essential compounds that hold vital biological activities to design novel therapies with enhanced efficacy compared to conventional treatments. Therefore, medicinal chemists used its core to synthesize new derivatives that can be applied to a variety of disorders. Benzofuran exhibited potential effectiveness in chronic diseases such as hypertension, neurodegenerative and oxidative conditions, and dyslipidemia. In acute infections, benzofuran revealed anti-infective properties against microorganisms like viruses, bacteria, and parasites. In recent years, the complex nature and the number of acquired or resistant cancer cases have been largely increasing. Benzofuran derivatives revealed potential anticancer activity with lower incidence or severity of adverse events normally encountered during chemotherapeutic treatments. This review discusses the structure-activity relationship (SAR) of several benzofuran derivatives in order to elucidate the possible substitution alternatives and structural requirements for a highly potent and selective anticancer activity.
DOI:doi:10.3390/cancers14092196
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/cancers14092196
 Volltext: https://www.mdpi.com/2072-6694/14/9/2196
 DOI: https://doi.org/10.3390/cancers14092196
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:anticancer activity
 anticancer potency
 anticancer selectivity
 benzofuran
 hybrid benzofurans
 SAR
K10plus-PPN:1881154408
Verknüpfungen:→ Zeitschrift

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