GLOS and HARM in patients with transient neurovascular symptoms with and without ischemic infarction

• Verfasst von: Förster, Alex [VerfasserIn]
• Verfasst von: Ramos, Ana [VerfasserIn]
• Verfasst von: Wenz, Holger [VerfasserIn]
• Verfasst von: Böhme, Johannes [VerfasserIn]
• Verfasst von: Groden, Christoph [VerfasserIn]
• Verfasst von: Alonso, Angelika [VerfasserIn]
• Titel: GLOS and HARM in patients with transient neurovascular symptoms with and without ischemic infarction
• Verf.angabe: A. Förster, Ana Ramos, H. Wenz, J Böhme, C. Groden, A. Alonso
• E-Jahr: 2022
• Jahr: May 2022
• Umfang: 6 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 6. April 2021, Artikelversion: 12. Mai 2022 ; Gesehen am 20.02.2024
• Titel Quelle: Enthalten in: Journal of neuroradiology
• Ort Quelle: Issy-les-Moulineaux : Elsevier Masson, 1995
• Jahr Quelle: 2022
• Band/Heft Quelle: 49(2022), 3 vom: Mai, Seite 244-249
• ISSN Quelle: 1773-0406
• DOI: doi:10.1016/j.neurad.2021.03.007
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Contrast-enhanced FLAIR
• Sach-SW: Gadolinium leakage
• Sach-SW: GLOS
• Sach-SW: Ocular
• Sach-SW: Transient ischemic attack
• Sach-SW: Transient neurovascular symptoms
• K10plus-PPN: 1881198790

Abstract

Background and purpose - Gadolinium leakage in ocular structures (GLOS) on fluid attenuated inversion recovery images (FLAIR) is a novel imaging marker in acute ischemic stroke and other neurological disorders. - Methods - In patients with transient neurovascular symptoms who underwent repeated MRI with intravenous contrast agent administration, the presence of acute ischemic lesions on diffusion-weighted images (DWI) as well as the frequency and pattern of blood-brain barrier and blood-retina barrier impairment as demonstrated by the hyperintense acute reperfusion marker (HARM) and GLOS respectively on postcontrast FLAIR were evaluated. - Results - Overall 28 patients with transient neurovascular symptoms (median age 70.5 years; 18 (64.3%) male) were included. Follow-up MRI was performed within 35 (IQR 21-47) hours after the initial MRI. On DWI, acute ischemic lesions were observed in 22 (78.6%). On contrast-enhanced FLAIR, GLOS was observed in 12 (42.9%) patients: in 1 (3.6%) only in the anterior chamber, and in 11 (39.3%) in the anterior chamber and vitreous body. HARM was observed in 3 (10.7%) patients. In one patient without ischemic lesion on DWI or HARM on FLAIR, GLOS was observed in the anterior chamber and vitreous body. Presence of GLOS was associated with higher age (p=0.04) and detection of HARM (p=0.03). - Conclusions - In patients with transient neurovascular symptoms, GLOS is a frequent finding and associated with HARM on contrast-enhanced FLAIR. As GLOS was observed in one patient without an ischemic lesion or HARM, it might be useful as an additional imaging marker.