Needle tract seeding and abdominal recurrence following pre-treatment biopsy of gastrointestinal stromal tumors (GIST)

• Verfasst von: Jakob, Jens [VerfasserIn]
• Verfasst von: Salameh, Rashad [VerfasserIn]
• Verfasst von: Wichmann, David [VerfasserIn]
• Verfasst von: Charalambous, Nicos [VerfasserIn]
• Verfasst von: Zygmunt, Anne-Christine [VerfasserIn]
• Verfasst von: Kreisel, Inga [VerfasserIn]
• Verfasst von: Heinz, Judith [VerfasserIn]
• Verfasst von: Ghadimi, Michael [VerfasserIn]
• Verfasst von: Ronellenfitsch, Ulrich [VerfasserIn]
• Titel: Needle tract seeding and abdominal recurrence following pre-treatment biopsy of gastrointestinal stromal tumors (GIST)
• Titelzusatz: results of a systematic review
• Verf.angabe: Jens Jakob, Rashad Salameh, David Wichmann, Nicos Charalambous, Anne-Christine Zygmunt, Inga Kreisel, Judith Heinz, Michael Ghadimi, and Ulrich Ronellenfitsch
• E-Jahr: 2022
• Jahr: 21 May 2022
• Fussnoten: Gesehen am 20.02.2024
• Titel Quelle: Enthalten in: BMC surgery
• Ort Quelle: London : BioMed Central, 2001
• Jahr Quelle: 2022
• Band/Heft Quelle: 22(2022), Artikel-ID 202, Seite 1-9$m9
• ISSN Quelle: 1471-2482
• DOI: doi:10.1186/s12893-022-01648-2
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1881227138

Abstract

Gastrointestinal stromal tumors (GIST) are rare abdominal tumors. Pretreatment biopsies may be used to diagnose a GIST and enable tailored treatment. Some experts are skeptical about biopsies because they fear tumor cell seeding. The objective of this study was to determine if pretreatment biopsy is associated with increased tumor recurrence. We performed a systematic literature search and included studies assessing the oncological outcome of GIST patients who underwent a pre-treatment core needle biopsy or fine needle aspiration. We assessed methodological quality with the Newcastle-Ottawa-Scale for non-randomized studies. This review was registered in the PROSPERO database (CRD42021170290). Three non-randomized studies and eight case reports comprising 350 patients were eligible for inclusion. No prospective study designed to answer the review question was found. One case of needle tract seeding after percutaneous core needle biopsy of GIST was reported. None of the studies reported an increased rate of abdominal recurrence in patients with pretreatment biopsy. The existing evidence does not indicate a relevant risk of needle tract seeding or abdominal recurrence after pre-treatment biopsy of GIST. Biopsy can safely be done to differentiate GIST from other tumors and to select the most appropriate treatment.