Mask continuous positive airway pressure increases diaphragm thickening fraction in healthy subjects

• Verfasst von: Lindner, Simon [VerfasserIn]
• Verfasst von: Teichert, Jan [VerfasserIn]
• Verfasst von: Hoermann, Clara [VerfasserIn]
• Verfasst von: Michels-Zetsche, Julia D. [VerfasserIn]
• Verfasst von: Herth, Felix [VerfasserIn]
• Verfasst von: Dürschmied, Daniel [VerfasserIn]
• Verfasst von: Britsch, Simone [VerfasserIn]
• Titel: Mask continuous positive airway pressure increases diaphragm thickening fraction in healthy subjects
• Verf.angabe: Simon Lindner, Jan Teichert, Clara Hoermann, Julia D. Michels, Felix J.F. Herth, Daniel Duerschmied, Simone Britsch
• E-Jahr: 2024
• Jahr: February 2024
• Umfang: 5 S.
• Fussnoten: Online veröffentlicht: 16. Januar 2024 ; Gesehen am 20.02.2024
• Titel Quelle: Enthalten in: Respiration
• Ort Quelle: Basel : Karger, 1968
• Jahr Quelle: 2024
• Band/Heft Quelle: 103(2024), 2 vom: Feb., Seite 100-104
• ISSN Quelle: 1423-0356
• DOI: doi:10.1159/000535990
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1881235122

Abstract

Introduction: The most widespread treatment for obstructive sleep apnoea and obesity hypoventilation syndrome is continuous positive airway pressure (CPAP). The addition of inspiratory support is a potential alternative. This is a physiological study to determine the effect of CPAP and inspiratory support pressure on respiratory effort measured by diaphragm thickening fraction (DTF) in healthy volunteers. Methods: DTF was measured in spontaneously breathing, healthy volunteers during 4 phases: (I) without connection to a ventilator, (II) on a ventilator without any applied pressures, (III) with a CPAP of 5 cmH2O, and (IV) with an additional inspiratory support pressure of 5 cmH2O. Results: Twenty-nine individuals agreed to participate. DTF was similar during the first two phases (32 ± 13% and 35 ± 22%). A considerable increase in DTF to 51 ± 21% was noted in phase III. The introduction of inspiratory support pressure during phase IV led to a reduction in DTF back to 36 ± 23% (p < 0.001). Tidal volume and minute ventilation were both slightly higher in phase IV compared to phase III. Conclusion: CPAP without inspiratory support pressure increases respiratory effort measured by DTF in healthy subjects. Further research is required to investigate this phenomenon in a clinical setting.