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| Verfasst von: | Zimmer, Jutta [VerfasserIn]  |
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| | Mueller, Louis [VerfasserIn] |
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| | Frank-Herrmann, Petra [VerfasserIn] |
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| | Rehnitz, Julia [VerfasserIn] |
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| | Dietrich, Jens Erik [VerfasserIn] |
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| | Bettendorf, Markus [VerfasserIn] |
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| | Strowitzki, Thomas [VerfasserIn] |
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| | Krivega, Maria [VerfasserIn] |
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| Titel: | Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans |
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| Verf.angabe: | J. Zimmer, L. Mueller, P. Frank-Herrmann, J. Rehnitz, J. E. Dietrich, M. Bettendorf, T. Strowitzki and M. Krivega |
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| E-Jahr: | 2024 |
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| Jahr: | 11 January 2024 |
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| Umfang: | 15 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 20.02.2024 |
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| Titel Quelle: | Enthalten in: Cell death & disease |
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| Ort Quelle: | London [u.a.] : Nature Publishing Group, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), 1, Seite 1-15 |
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| ISSN Quelle: | 2041-4889 |
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| Abstract: | Development of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship between androgens and genomic integrity determining human fertility. We used different study groups: individuals with Differences of Sex Development (DSD), including Complete Androgen Insensitivity Syndrome (CAIS) due to mutated androgen receptor (AR), and men with idiopathic nonobstructive azoospermia. Both showed genome integrity status influenced by androgen signaling via innate immune response activation in blood and gonads. Whole proteome analysis connected low AR to interleukin-specific gene expression, while compromised genome stability and tumorigenesis were also supported by interferons. AR expression was associated with predominant DNA damage phenotype, that eliminated AR-positive Sertoli cells as the degeneration of gonads increased. Low AR contributed to resistance from the inhibition of DNA repair in primary leukocytes. Downregulation of androgen promoted apoptosis and specific innate immune response with higher susceptibility in cells carrying genomic instability. |
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| DOI: | doi:10.1038/s41419-023-06397-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41419-023-06397-5 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41419-023-06397-5 |
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| | DOI: https://doi.org/10.1038/s41419-023-06397-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Apoptosis |
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| | Cancer genomics |
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| | Embryology |
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| | Germ cell tumours |
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| | Spermatogenesis |
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| K10plus-PPN: | 1881243214 |
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| Verknüpfungen: | → Zeitschrift |
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Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans / Zimmer, Jutta [VerfasserIn]; 11 January 2024 (Online-Ressource)
