Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Alzaid, Haidar [VerfasserIn]   i
 Simon, Joe J. [VerfasserIn]   i
 Brugnara, Gianluca [VerfasserIn]   i
 Vollmuth, Philipp [VerfasserIn]   i
 Bendszus, Martin [VerfasserIn]   i
 Friederich, Hans-Christoph [VerfasserIn]   i
Titel:Hypothalamic subregion alterations in anorexia nervosa and obesity
Titelzusatz:association with appetite-regulating hormone levels
Verf.angabe:Haidar Alzaid, MD, Joe J. Simon, PhD, Gianluca Brugnara, MD, Philipp Vollmuth, MD, Martin Bendszus, MD, Hans-Christoph Friederich, MD
E-Jahr:2024
Jahr:19 January 2024
Umfang:12 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 21.02.2024
Titel Quelle:Enthalten in: The international journal of eating disorders
Ort Quelle:New York, NY : Wiley, 1981
Jahr Quelle:2024
Band/Heft Quelle:(2024) online ahead of print
ISSN Quelle:1098-108X
Abstract:Objective Anorexia nervosa (AN) and obesity are weight-related disorders with imbalances in energy homeostasis that may be due to hormonal dysregulation. Given the importance of the hypothalamus in hormonal regulation, we aimed to identify morphometric alterations to hypothalamic subregions linked to these conditions and their connection to appetite-regulating hormones. Methods Structural magnetic resonance imaging (MRI) was obtained from 78 patients with AN, 27 individuals with obesity and 100 normal-weight healthy controls. Leptin, ghrelin, and insulin blood levels were measured in a subsample of each group. An automated segmentation method was used to segment the hypothalamus and its subregions. Volumes of the hypothalamus and its subregions were compared between groups, and correlational analysis was employed to assess the relationship between morphometric measurements and appetite-regulating hormone levels. Results While accounting for total brain volume, patients with AN displayed a smaller volume in the inferior-tubular subregion (ITS). Conversely, obesity was associated with a larger volume in the anterior-superior, ITS, posterior subregions (PS), and entire hypothalamus. There were no significant volumetric differences between AN subtypes. Leptin correlated positively with PS volume, whereas ghrelin correlated negatively with the whole hypothalamus volume in the entire cohort. However, appetite-regulating hormone levels did not mediate the effects of body mass index on volumetric measures. Conclusion Our results indicate the importance of regional structural hypothalamic alterations in AN and obesity, extending beyond global changes to brain volume. Furthermore, these alterations may be linked to changes in hormonal appetite regulation. However, given the small sample size in our correlation analysis, further analyses in a larger sample size are warranted. Public Significance Using an automated segmentation method to investigate morphometric alterations of hypothalamic subregions in AN and obesity, this study provides valuable insights into the complex interplay between hypothalamic alterations, hormonal appetite regulation, and body weight, highlighting the need for further research to uncover underlying mechanisms.
DOI:doi:10.1002/eat.24137
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1002/eat.24137
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eat.24137
 DOI: https://doi.org/10.1002/eat.24137
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:anorexia nervosa
 appetite-regulating hormones
 BMI
 hypothalamus
 obesity
 structural MRI
K10plus-PPN:1881321959
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69184457   QR-Code
zum Seitenanfang