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| Verfasst von: | Schwegler, Niklas [VerfasserIn]  |
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| | Gebert, Tanisha [VerfasserIn] |
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| | Villiou, Maria [VerfasserIn] |
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| | Colombo, Federico [VerfasserIn] |
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| | Schamberger, Barbara [VerfasserIn] |
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| | Selhuber-Unkel, Christine [VerfasserIn] |
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| | Thomas, Franziska [VerfasserIn] |
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| | Blasco, Eva [VerfasserIn] |
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| Titel: | Multimaterial 3D laser printing of cell-adhesive and cell-repellent hydrogels |
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| Verf.angabe: | Niklas Schwegler, Tanisha Gebert, Maria Villiou, Federico Colombo, Barbara Schamberger, Christine Selhuber-Unkel, Franziska Thomas, and Eva Blasco |
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| Ausgabe: | Version 1 |
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| E-Jahr: | 2024 |
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| Jahr: | 17 January 2024 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 21.02.2024 |
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| Titel Quelle: | Enthalten in: ChemRxiv |
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| Ort Quelle: | [Washington, DC] : American Chemical Society (ACS), 2018 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | (2024) vom: 17. Jan., Seite 1-13 |
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| Abstract: | This study introduces a straightforward method for manufacturing 3D microstructured cell-adhesive and cell-repellent multimaterials using two-photon laser printing. Compared to existing strategies, this approach offers bottom-up molecular control, high customizability and rapid and precise 3D fabrication. The printable cell-adhesive PEG-based material includes an RGD-containing peptide synthesized through solid-phase peptide synthesis, allowing for precise control of the peptide design. Remarkably, minimal amounts of RGD peptide (< 0.1 wt%) suffice for imparting cell-adhesiveness, while maintaining identical mechanical properties in the 3D printed microstructures to those of the cell-repellent, PEG-based material. Fluorescent labeling of the RGD peptide facilitates visualization of its presence in cell-adhesive areas. To demonstrate the broad applicability of our system, we showcase the fabrication of cell-adhesive 2.5D and 3D structures, fostering the adhesion of fibroblast cells within these architectures. Thus, this approach allows for the printing of high-resolution, true 3D structures suitable for diverse applications, including cellular studies in complex environments. |
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| DOI: | doi:10.26434/chemrxiv-2024-f94sf |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.26434/chemrxiv-2024-f94sf |
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| | Volltext: https://chemrxiv.org/engage/chemrxiv/article-details/65a63933e9ebbb4db943fa99 |
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| | DOI: https://doi.org/10.26434/chemrxiv-2024-f94sf |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Forschungsdaten: Schwegler, Niklas, 1998 - : Multimaterial 3D laser printing of cell-adhesive and cell-repellent hydrogels [data] |
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| Sach-SW: | cell adhesion |
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| | direct laser writing |
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| | hydrogels |
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| | RGD |
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| | two-photon |
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| K10plus-PPN: | 1881333272 |
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| Verknüpfungen: | → Sammelwerk |
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Multimaterial 3D laser printing of cell-adhesive and cell-repellent hydrogels / Schwegler, Niklas [VerfasserIn]; 17 January 2024 (Online-Ressource)
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