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Verfasst von:Diedler, Jennifer [VerfasserIn]   i
 Karpel-Massler, Georg [VerfasserIn]   i
 Sykora, Marek [VerfasserIn]   i
 Poli, Sven [VerfasserIn]   i
 Sakowitz, Oliver [VerfasserIn]   i
 Veltkamp, Roland [VerfasserIn]   i
 Steiner, Thorsten [VerfasserIn]   i
Titel:Autoregulation and brain metabolism in the perihematomal region of spontaneous intracerebral hemorrhage
Titelzusatz:an observational pilot study
Verf.angabe:Jennifer Diedler, Georg Karpel-Massler, Marek Sykora, Sven Poli, Oliver W. Sakowitz, Roland Veltkamp, Thorsten Steiner
E-Jahr:2010
Jahr:16 June 2010
Umfang:7 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 26.02.2024
Titel Quelle:Enthalten in: Journal of the neurological sciences
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1964
Jahr Quelle:2010
Band/Heft Quelle:295(2010), 1/2 vom: Aug., Seite 16-22
ISSN Quelle:1878-5883
Abstract:The metabolic and hemodynamic processes in the edema surrounding spontaneous, supratentorial intracerebral hemorrhage (ICH) are poorly understood. Specifically, the local metabolic effects of autoregulatory failure have not been described previously. In the current observational pilot study, microdialysis and brain tissue oxygenation probes (P(br)O(2)) were placed in the perihemorrhagic edema using neuronavigation in five non-surgically treated patients with deep ICH. The cerebrovascular pressure reactivity index (PRx, moving correlation between mean arterial and intracranial pressure) and P(br)O(2) reactivity index (ORx, correlation between P(br)O(2) and cerebral perfusion pressure) were used to characterize cerebral autoregulation. While all five patients had ORx values indicative for severely disturbed autoregulation, assessment of PRx only in one patient was consistent with sustained failure of cerebrovascular reactivity. This patient at the same time had the worst metabolic parameters and the poorest tissue oxygenation. We conclude that multimodality monitoring in the perihemorrhagic penumbra is feasible. A study in a larger population is needed to clarify the relationship between PRx and ORx in ICH patients, the local metabolic effects of autoregulatory failure and its relation to brain edema formation and clinical outcome.
DOI:doi:10.1016/j.jns.2010.05.027
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.jns.2010.05.027
 DOI: https://doi.org/10.1016/j.jns.2010.05.027
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aged
 Blood Pressure
 Brain
 Brain Edema
 Cerebral Hemorrhage
 Cerebrovascular Circulation
 Female
 Heart Rate
 Homeostasis
 Humans
 Intracranial Pressure
 Magnetic Resonance Imaging
 Male
 Microdialysis
 Middle Aged
 Observation
 Oxygen Consumption
 Pilot Projects
 Retrospective Studies
 Time Factors
K10plus-PPN:1881605647
Verknüpfungen:→ Zeitschrift

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