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| Verfasst von: | Wilms, Henrik [VerfasserIn]  |
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| | Sievers, Jobst [VerfasserIn] |
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| | Rickert, Uta [VerfasserIn] |
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| | Rostami-Yazdi, Martin [VerfasserIn] |
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| | Mrowietz, Ulrich [VerfasserIn] |
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| | Lucius, Ralph [VerfasserIn] |
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| Titel: | Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation |
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| Verf.angabe: | Henrik Wilms, Jobst Sievers, Uta Rickert, Martin Rostami-Yazdi, Ulrich Mrowietz and Ralph Lucius |
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| E-Jahr: | 2010 |
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| Jahr: | 19 May 2010 |
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| Umfang: | 8 S. |
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| Illustrationen: | Illustrationen, Diagramme |
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| Fussnoten: | Gesehen am 26.02.2024 |
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| Titel Quelle: | Enthalten in: Journal of neuroinflammation |
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| Ort Quelle: | London : BioMed Central, 2004 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 7(2010), Artikel-ID 30, Seite 1-8 |
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| ISSN Quelle: | 1742-2094 |
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| Abstract: | Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to ameliorate the course of relapsing-remitting MS. Glial cells are the effector cells of neuroinflammation; however, little is known of the effect of DMF on microglia and astrocytes. The purpose of this study was to use an established in vitro model of brain inflammation to determine if DMF modulates the release of neurotoxic molecules from microglia and astrocytes, thus inhibiting glial inflammation. |
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| DOI: | doi:10.1186/1742-2094-7-30 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1186/1742-2094-7-30 |
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| | DOI: https://doi.org/10.1186/1742-2094-7-30 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Experimental Autoimmune Encephalomyelitis |
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| | Microglial Cell |
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| | Multiple Sclerosis |
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| | Natalizumab |
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| | Nitric Oxide |
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| K10plus-PPN: | 1881617459 |
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| Verknüpfungen: | → Zeitschrift |
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Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation / Wilms, Henrik [VerfasserIn]; 19 May 2010 (Online-Ressource)
