Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Wimmer, Verena C. [VerfasserIn]  |
| Broser, Philip Julian [VerfasserIn]  |
| Kuner, Thomas [VerfasserIn]  |
| Bruno, Randy M. [VerfasserIn]  |
Titel: | Experience-induced plasticity of thalamocortical axons in both juveniles and adults |
Verf.angabe: | Verena C. Wimmer, Philip J. Broser, Thomas Kuner, and Randy M. Bruno |
E-Jahr: | 2010 |
Jahr: | 15 November 2010 |
Umfang: | 20 S. |
Illustrationen: | Illustrationen, Diagramme |
Fussnoten: | First published: 26 August 2010 ; Gesehen am 26.02.2024 |
Titel Quelle: | Enthalten in: The journal of comparative neurology |
Ort Quelle: | New York, NY [u.a.] : Wiley-Liss, 1891 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 518(2010), 22 vom: Nov., Seite 4629-4648 |
ISSN Quelle: | 1096-9861 |
Abstract: | We examined the effect of sensory deprivation on thalamocortical (TC) projections to the rat primary somatosensory cortex at different postnatal ages ranging from P0 to P96. Rats had their whiskers clipped off with one or two vibrissae spared. TC axons innervating barrel cortex were specifically labeled by injecting virus expressing fluorescent proteins into the corresponding primary (VPM) and/or secondary (POm) thalamic nuclei. The density of VPM axons in deprived columns was ≈34% lower relative to spared columns with a concomitant decrease in bouton density, suggesting a deprivation-induced retraction of VPM axons. Axonal changes were reversible upon regrowth of the clipped whiskers and independent of age at deprivation, indicating the absence of a critical period for anatomical plasticity. The POm projection was not obviously altered by sensory deprivation. We suggest that retraction and regrowth of TC axons substantially contribute to long-term deprivation-dependent functional plasticity. J. Comp. Neurol. 518:4629-4648, 2010. © 2010 Wiley-Liss, Inc. |
DOI: | doi:10.1002/cne.22483 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/cne.22483 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.22483 |
| DOI: https://doi.org/10.1002/cne.22483 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | adenoassociated virus |
| barrel cortex |
| deprivation |
| environmental enrichment |
| plasticity |
| thalamocortical |
K10plus-PPN: | 1881624765 |
Verknüpfungen: | → Zeitschrift |
Experience-induced plasticity of thalamocortical axons in both juveniles and adults / Wimmer, Verena C. [VerfasserIn]; 15 November 2010 (Online-Ressource)
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