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Status: Bibliographieeintrag

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Verfasst von:Richter, Anja [VerfasserIn]   i
 Al-Bayati, Mohammad [VerfasserIn]   i
 Paraskevopoulou, Foteini [VerfasserIn]   i
 Krämer, Bernd [VerfasserIn]   i
 Pruessner, Jens C. [VerfasserIn]   i
 Binder, Elisabeth B. [VerfasserIn]   i
 Gruber, Oliver [VerfasserIn]   i
Titel:Interaction of FKBP5 variant rs3800373 and city living alters the neural stress response in the anterior cingulate cortex
Verf.angabe:Anja Richter, Mohammad Al-Bayati, Foteini Paraskevopoulou, Bernd Krämer, Jens C. Pruessner, Elisabeth B. Binder and Oliver Gruber
E-Jahr:2021
Jahr:08 Feb 2021
Umfang:9 S.
Fussnoten:Gesehen am 29.02.2024
Titel Quelle:Enthalten in: Stress
Ort Quelle:Abingdon : Taylor & Francis Group, 1996
Jahr Quelle:2021
Band/Heft Quelle:24(2021), 4, Seite 421-429
ISSN Quelle:1607-8888
Abstract:Psychosocial stress effects of urban living are associated with substantially increased risk for schizophrenia, mood and anxiety disorders, by altering stress-induced activity in the amygdala and pregenual anterior cingulate cortex (ACC). Genetic factors are likely to modulate the impact of city living on stress processing. Growing evidence suggests a key role of FKBP5, a co-chaperone regulating the glucocorticoid receptor sensitivity, in the etiology of stress-related disorders. Here we investigated the interaction of city living and genetic variation in FKBP5 (rs3800373) on neural activity in stress-sensitive brain systems. Functional magnetic resonance imaging was performed in 31 healthy young adults using the Montreal Imaging Stress Task. Subjects were divided into groups depending on the number of inhabitants of their current residency. There was a significant main effect of city living on neural activity in the amygdala-hippocampus complex, replicating prior findings. Moreover, we found an interaction between rs3800373 and city living modulating responses in the bilateral subgenual ACC and right pregenual ACC. Specifically, only city dwellers carrying the FKBP5 minor risk allele showed increased stress responses in the subgenual and pregenual ACC when compared to those living in small towns. A significant gene-environment interaction on neural stress responses in the amygdala or hippocampus was only found in FKBP5 major allele carriers. These results point to a potential role of the FKBP5 rs3800373 minor risk allele in predisposing those who live in bigger cities to changes of functional responsivity in the pre- and subgenual ACC, thereby increasing the risk for developing stress-related mental disorders.
DOI:doi:10.1080/10253890.2020.1855420
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1080/10253890.2020.1855420
 DOI: https://doi.org/10.1080/10253890.2020.1855420
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:fMRI
 Gene x environment interaction
 montreal imaging stress task
 psychosocial stress
 urban upbringing
K10plus-PPN:1882190858
Verknüpfungen:→ Zeitschrift

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