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Status: Bibliographieeintrag

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Verfasst von:Deo, Abhilash [VerfasserIn]   i
 Sleeman, Jonathan P. [VerfasserIn]   i
 Shaked, Yuval [VerfasserIn]   i
Titel:The role of host response to chemotherapy
Titelzusatz:resistance, metastasis and clinical implications: review
Verf.angabe:Abhilash Deo, Jonathan P. Sleeman, Yuval Shaked
E-Jahr:2023
Jahr:24 November 2023
Umfang:13 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 29.02.2024
Titel Quelle:Enthalten in: Clinical & experimental metastasis
Ort Quelle:Dordrecht : Springer Science + Business Media B.V., 1983
Jahr Quelle:2023
Band/Heft Quelle:(2023), Seite 1-13
ISSN Quelle:1573-7276
Abstract:Chemotherapy remains the primary treatment for most metastatic cancers. However, the response to chemotherapy and targeted agents is often transient, and concurrent development of resistance is the primary impediment to effective cancer therapy. Strategies to overcome resistance to treatment have focused on cancer cell intrinsic factors and the tumor microenvironment (TME). Recent evidence indicates that systemic chemotherapy has a significant impact on the host that either facilitates tumor growth, allowing metastatic spread, or renders treatment ineffective. These host responses include the release of bone marrow-derived cells, activation of stromal cells in the TME, and induction of different molecular effectors. Here, we provide an overview of chemotherapy-induced systemic host responses that support tumor aggressiveness and metastasis, and which contribute to therapy resistance. Studying host responses to chemotherapy provides a solid basis for the development of adjuvant strategies to improve treatment outcomes and delay resistance to chemotherapy. This review discusses the emerging field of host response to cancer therapy, and its preclinical and potential clinical implications, explaining how under certain circumstances, these host effects contribute to metastasis and resistance to chemotherapy.
DOI:doi:10.1007/s10585-023-10243-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s10585-023-10243-5
 Volltext: https://link.springer.com/article/10.1007/s10585-023-10243-5
 DOI: https://doi.org/10.1007/s10585-023-10243-5
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Chemoresistance
 Host response
 Metastasis
 Tumor microenvironment
K10plus-PPN:1882192427
Verknüpfungen:→ Zeitschrift

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