Status: Bibliographieeintrag
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| Verfasst von: | Gutjahr, Ewgenija [VerfasserIn]  |
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| | Fremd, Carlo [VerfasserIn] |
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| | Arnscheidt, Johanna [VerfasserIn] |
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| | Penzel, Roland [VerfasserIn] |
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| | Wacker, Jürgen [VerfasserIn] |
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| | Sinn, Peter [VerfasserIn] |
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| Titel: | Non-response of Epstein-Barr virus-associated breast cancer after primary chemotherapy |
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| Titelzusatz: | report of two cases |
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| Verf.angabe: | Ewgenija Gutjahr, Carlo Fremd, Johanna Arnscheidt, Roland Penzel, Jürgen Wacker and Peter Sinn |
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| E-Jahr: | 2023 |
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| Jahr: | 24 November 2023 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 01.03.2024 |
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| Titel Quelle: | Enthalten in: Pathogens |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 12(2023), 12, Artikel-ID 1387, Seite 1-10 |
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| ISSN Quelle: | 2076-0817 |
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| Abstract: | Based on epidemiological evidence and molecular findings, a possible association of Epstein-Barr virus (EBV) with the carcinogenesis of breast cancer has been described. However, the frequency of EBV in breast cancer and the role of EBV regarding tumor progression or therapeutic results is largely unexplored. Here, we report on two cases of advanced, lymph node-positive invasive breast cancer of no special type (NST), histologically showing no clinical or histological evidence of tumor regression as an equivalent of a lack of response to primary systemic therapy. Both tumors were considered to be EBV-associated due to their positivity in EBV-encoded RNA (EBER) in situ hybridization (ISH) and their immunoreactivity against EBV Epstein-Barr nuclear antigen 1 (EBNA1). We hypothesize that the unusual non-response to chemotherapy in these cases of breast cancer classified as triple-negative and HER2-positive may be linked to the EBV co-infection of tumor cells. Therefore, EBV tumor testing should be considered in patients with breast cancer presenting with resistance to chemotherapy. This hypothesis may provide a new aspect in the context of EBV-associated mechanisms of tumor progression. |
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| DOI: | doi:10.3390/pathogens12121387 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/pathogens12121387 |
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| | Volltext: https://www.mdpi.com/2076-0817/12/12/1387 |
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| | DOI: https://doi.org/10.3390/pathogens12121387 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | breast cancer |
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| | EBV |
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| | therapy resistance |
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| K10plus-PPN: | 1882319680 |
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| Verknüpfungen: | → Zeitschrift |
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Non-response of Epstein-Barr virus-associated breast cancer after primary chemotherapy / Gutjahr, Ewgenija [VerfasserIn]; 24 November 2023 (Online-Ressource)
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