| |  Online-Ressource |
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| Verfasst von: | Woo, Marcel Seungsu [VerfasserIn]  |
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| | Ufer, Friederike [VerfasserIn] |
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| | Sonner, Jana K. [VerfasserIn] |
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| | Belkacemi, Anouar [VerfasserIn] |
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| | Tintelnot, Joseph [VerfasserIn] |
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| | Sáez, Pablo J. [VerfasserIn] |
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| | Krieg, Paula F. [VerfasserIn] |
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| | Mayer, Christina [VerfasserIn] |
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| | Binkle-Ladisch, Lars [VerfasserIn] |
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| | Engler, Jan Broder [VerfasserIn] |
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| | Bauer, Simone [VerfasserIn] |
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| | Kursawe, Nina [VerfasserIn] |
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| | Vieira, Vanessa [VerfasserIn] |
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| | Mannebach, Stefanie [VerfasserIn] |
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| | Freichel, Marc [VerfasserIn] |
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| | Flockerzi, Veit [VerfasserIn] |
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| | Vargas, Pablo [VerfasserIn] |
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| | Friese, Manuel A. [VerfasserIn] |
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| Titel: | Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells |
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| Verf.angabe: | Marcel S. Woo, Friederike Ufer, Jana K. Sonner, Anouar Belkacemi, Joseph Tintelnot, Pablo J. Sáez, Paula F. Krieg, Christina Mayer, Lars Binkle-Ladisch, Jan Broder Engler, Simone Bauer, Nina Kursawe, Vanessa Vieira, Stefanie Mannebach, Marc Freichel, Veit Flockerzi, Pablo Vargas, Manuel A. Friese |
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| E-Jahr: | 2023 |
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| Jahr: | 20 Sep 2023 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 01.03.2024 |
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| Titel Quelle: | Enthalten in: Science advances |
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| Ort Quelle: | Washington, DC [u.a.] : Assoc., 2015 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 9(2023), 38, Artikel-ID eadh1653, Seite 1-11 |
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| ISSN Quelle: | 2375-2548 |
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| Abstract: | Migratory dendritic cells (migDCs) continuously patrol tissues and are activated by injury and inflammation. Extracellular adenosine triphosphate (ATP) is released by damaged cells or actively secreted during inflammation and increases migDC motility. However, the underlying molecular mechanisms by which ATP accelerates migDC migration is not understood. Here, we show that migDCs can be distinguished from other DC subsets and immune cells by their expression of the voltage-gated calcium channel subunit β3 (Cavβ3; CACNB3), which exclusively facilitates ATP-dependent migration in vitro and during tissue damage in vivo. By contrast, CACNB3 does not regulate lipopolysaccharide-dependent migration. Mechanistically, CACNB3 regulates ATP-dependent inositol 1,4,5-trisphophate receptor-controlled calcium release from the endoplasmic reticulum. This, in turn, is required for ATP-mediated suppression of adhesion molecules, their detachment, and initiation of migDC migration. Thus, Cacnb3-deficient migDCs have an impaired migration after ATP exposure. In summary, we identified CACNB3 as a master regulator of ATP-dependent migDC migration that controls tissue-specific immunological responses during injury and inflammation. |
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| DOI: | doi:10.1126/sciadv.adh1653 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1126/sciadv.adh1653 |
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| | kostenfrei: Volltext: https://www.science.org/doi/10.1126/sciadv.adh1653 |
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| | DOI: https://doi.org/10.1126/sciadv.adh1653 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1882347390 |
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| Verknüpfungen: | → Zeitschrift |
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Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells / Woo, Marcel Seungsu [VerfasserIn]; 20 Sep 2023 (Online-Ressource)
