Increased aldosterone-18-glucuronide/tetrahydro-aldosterone ratios in pregnancy

• Verfasst von: Wacker, Jürgen [VerfasserIn]
• Verfasst von: Piel, P. [VerfasserIn]
• Verfasst von: Lewicka, Sabina [VerfasserIn]
• Verfasst von: Haack, Doris [VerfasserIn]
• Verfasst von: Vecsei, Pál [VerfasserIn]
• Verfasst von: Bastert, Gunther [VerfasserIn]
• Titel: Increased aldosterone-18-glucuronide/tetrahydro-aldosterone ratios in pregnancy
• Verf.angabe: J. Wacker, P. Piel, S. Lewicka, D. Haack, P. Vecsei, G. Bastert
• Jahr: 1995
• Umfang: 6 S.
• Fussnoten: Elektronische Reproduktion der Druck-Ausgabe 7. Juli 2009 ; Gesehen am 07.03.2024
• Titel Quelle: Enthalten in: Endocrine research
• Ort Quelle: Abingdon : Taylor & Francis Group, 1984
• Jahr Quelle: 1995
• Band/Heft Quelle: 21(1995), 1-2, Seite 197-202
• ISSN Quelle: 1532-4206
• DOI: doi:10.3109/07435809509030435
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1882879287

Abstract

In the present study the aldosterone-18-glucuronide and tetrahydroaldosterone values in 24 hour urine collections of healthy nonpregnant women, women with normal pregnancies and women with pregnancy induced hypertension (PIH) were compared. In pregnancy an elevated excretion of both aldosterone metabolites was found. The Q-ratio (aldosterone-18-glucuronide / tetrahydro-aldosterone + aldosterone-18-glucuronide) was also increased compared to healthy nonpregnant women. The elevated Q-ratios point out to increased formation of aldosterone-18-glucuronide. This predominantly renal metabolite may reflect greater availability of aldosterone molecules for interaction with mineralocorticoid receptor in the kidney.