| Online-Ressource |
Verfasst von: | Mori, Yuriko [VerfasserIn]  |
| Kramer, Vasko [VerfasserIn]  |
| Novruzov, Emil [VerfasserIn]  |
| Mamlins, Eduards [VerfasserIn]  |
| Röhrich, Manuel [VerfasserIn]  |
| Fernandez, Rene [VerfasserIn]  |
| Amaral, Horacio [VerfasserIn]  |
| Soza-Ried, Cristian A. [VerfasserIn]  |
| Monje, Barbara [VerfasserIn]  |
| Sabbagh, Eduardo [VerfasserIn]  |
| Florenzano, Matias [VerfasserIn]  |
| Giesel, Frederik L. [VerfasserIn]  |
| Undurraga, Alvaro [VerfasserIn]  |
Titel: | Initial results with (18F)FAPI‑74 PET/CT in idiopathic pulmonary fibrosis |
Verf.angabe: | Yuriko Mori, Vasko Kramer, Emil Novruzov, Eduards Mamlins, Manuel Roehrich, Rene Fernandez, Horacio Amaral, Cristian Soza-Ried, Barbara Monje, Eduardo Sabbagh, Matias Florenzano, Frederik L. Giesel & Alvaro Undurraga |
E-Jahr: | 2023 |
Jahr: | 20 December 2023 |
Umfang: | 7 S. |
Fussnoten: | Im Titel steht 18F in eckiger Klammer, die Zahl 18 ist dabei hochgestellt ; Gesehen am 11.03.2024 |
Titel Quelle: | Enthalten in: European journal of nuclear medicine and molecular imaging |
Ort Quelle: | Heidelberg [u.a.] : Springer-Verl., 2002 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 51(2024), 6, Seite 1605-1611 |
ISSN Quelle: | 1619-7089 |
Abstract: | Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis. Ga-68-labeled FAP ligands exhibited highly promising results due to the crucial role of activated fibroblasts in fibrosis imaging of the lung. However, F-18-labeled FAP ligands might provide qualitatively much higher imaging results with accompanying economic benefits due to large-scale production. Thus, we sought to investigate the potential of [F-18]FAPI-74 prospectively in a small patient cohort.Methods: Eight patients underwent both [F-18]FAPI-74-PET/CT and HRCT scans and were then compared with a control group without any fibrosing pulmonary disease. The tracer uptake of fibrotic lung areas was analyzed in synopsis with radiological and clinical parameters.Results: We observed a positive correlation between the fibrotic active volume, the Hounsfield scale, as well as the vital and diffusing capacity of the lung.Conclusion: The initial results confirm our assumption that [F-18]FAPI-74 offers a viable non-invasive assessment method for pulmonary fibrotic changes in patients with IPF. |
DOI: | doi:10.1007/s00259-023-06564-y |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1007/s00259-023-06564-y |
| kostenfrei: Volltext: https://link.springer.com/article/10.1007/s00259-023-06564-y |
| DOI: https://doi.org/10.1007/s00259-023-06564-y |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | FAPI |
| Fibroblast activation protein |
| Fibrosis |
| Idiopathic pulmonary disease |
| PET |
K10plus-PPN: | 1883101972 |
Verknüpfungen: | → Zeitschrift |
Initial results with (18F)FAPI‑74 PET/CT in idiopathic pulmonary fibrosis / Mori, Yuriko [VerfasserIn]; 20 December 2023 (Online-Ressource)