| |  Online-Ressource |
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| Verfasst von: | Mori, Yuriko [VerfasserIn]  |
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| | Kramer, Vasko [VerfasserIn] |
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| | Novruzov, Emil [VerfasserIn] |
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| | Mamlins, Eduards [VerfasserIn] |
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| | Röhrich, Manuel [VerfasserIn] |
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| | Fernandez, Rene [VerfasserIn] |
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| | Amaral, Horacio [VerfasserIn] |
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| | Soza-Ried, Cristian A. [VerfasserIn] |
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| | Monje, Barbara [VerfasserIn] |
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| | Sabbagh, Eduardo [VerfasserIn] |
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| | Florenzano, Matias [VerfasserIn] |
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| | Giesel, Frederik L. [VerfasserIn] |
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| | Undurraga, Alvaro [VerfasserIn] |
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| Titel: | Initial results with (18F)FAPI‑74 PET/CT in idiopathic pulmonary fibrosis |
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| Verf.angabe: | Yuriko Mori, Vasko Kramer, Emil Novruzov, Eduards Mamlins, Manuel Roehrich, Rene Fernandez, Horacio Amaral, Cristian Soza-Ried, Barbara Monje, Eduardo Sabbagh, Matias Florenzano, Frederik L. Giesel & Alvaro Undurraga |
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| E-Jahr: | 2023 |
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| Jahr: | 20 December 2023 |
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| Umfang: | 7 S. |
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| Fussnoten: | Im Titel steht 18F in eckiger Klammer, die Zahl 18 ist dabei hochgestellt ; Gesehen am 11.03.2024 |
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| Titel Quelle: | Enthalten in: European journal of nuclear medicine and molecular imaging |
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| Ort Quelle: | Heidelberg [u.a.] : Springer-Verl., 2002 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 51(2024), 6, Seite 1605-1611 |
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| ISSN Quelle: | 1619-7089 |
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| Abstract: | Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis. Ga-68-labeled FAP ligands exhibited highly promising results due to the crucial role of activated fibroblasts in fibrosis imaging of the lung. However, F-18-labeled FAP ligands might provide qualitatively much higher imaging results with accompanying economic benefits due to large-scale production. Thus, we sought to investigate the potential of [F-18]FAPI-74 prospectively in a small patient cohort.Methods: Eight patients underwent both [F-18]FAPI-74-PET/CT and HRCT scans and were then compared with a control group without any fibrosing pulmonary disease. The tracer uptake of fibrotic lung areas was analyzed in synopsis with radiological and clinical parameters.Results: We observed a positive correlation between the fibrotic active volume, the Hounsfield scale, as well as the vital and diffusing capacity of the lung.Conclusion: The initial results confirm our assumption that [F-18]FAPI-74 offers a viable non-invasive assessment method for pulmonary fibrotic changes in patients with IPF. |
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| DOI: | doi:10.1007/s00259-023-06564-y |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1007/s00259-023-06564-y |
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| | kostenfrei: Volltext: https://link.springer.com/article/10.1007/s00259-023-06564-y |
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| | DOI: https://doi.org/10.1007/s00259-023-06564-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | FAPI |
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| | Fibroblast activation protein |
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| | Fibrosis |
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| | Idiopathic pulmonary disease |
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| | PET |
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| K10plus-PPN: | 1883101972 |
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| Verknüpfungen: | → Zeitschrift |
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Initial results with (18F)FAPI‑74 PET/CT in idiopathic pulmonary fibrosis / Mori, Yuriko [VerfasserIn]; 20 December 2023 (Online-Ressource)
