Editorial

• Verfasst von: Younsi, Alexander [VerfasserIn]
• Titel: Editorial
• Titelzusatz: neurotrauma and repair: from peripheral to central nerve injury
• Verf.angabe: Alexander Younsi
• E-Jahr: 2023
• Jahr: 01 December 2023
• Umfang: 2 S.
• Fussnoten: Gesehen am 12.03.2024
• Titel Quelle: Enthalten in: Frontiers in molecular neuroscience
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2008
• Jahr Quelle: 2023
• Band/Heft Quelle: 16(2023), Seite 1-2
• ISSN Quelle: 1662-5099
• DOI: doi:10.3389/fnmol.2023.1338869
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Neuroregeneration
• Sach-SW: neurotrauma
• Sach-SW: peripheral nerve injury
• Sach-SW: spinal cord injury
• Sach-SW: Traumatic Brain Injury
• K10plus-PPN: 1883156882

Abstract

Neurotrauma, encompassing traumatic brain injury (TBI), peripheral nerve injury (PNI), and spinal cord injury (SCI), continues to be a major global public health concern. The complex pathophysiological mechanisms and lifelong neurological deficits associated with neurotrauma emphasize the urgent need for effective clinical interventions. The research topic "Neurotrauma and Repair: from Peripheral to Central Nerve Injury" brought together a diverse group of 58 authors, fostering interdisciplinary collaboration, and offering new insights into the multifaceted landscape of neurotrauma research.This collaborative effort yielded a body of work that has garnered significant attention within the scientific community, underscoring the importance of the research contributions and the demand for advances in neurotrauma understanding and treatment."Effects of a Neurokinin-1 Receptor Antagonist in the Acute Phase after Thoracic Spinal Cord Injury in a Rat Model" delves into the potential therapeutic effects of neurokinin-1 receptor antagonists on neuroinflammation and edema following SCI. While the study suggests limited impact on reducing edema, it demonstrates a notable reduction in T-lymphocyte invasion and apoptotic cell numbers with the treatment. Additionally, it hints at a trend towards reduced fibrinogen leakage, endothelial and microglial activation, chondroitin sulfate glycosaminoglycan deposition, and astrogliosis. Although general locomotion recovery remained modest, the C...