| |  Online-Ressource |
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| Verfasst von: | Carai, Paolo [VerfasserIn]  |
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| | Papageorgiou, Anna Pia [VerfasserIn] |
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| | Van Linthout, Sophie [VerfasserIn] |
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| | Deckx, Sophie [VerfasserIn] |
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| | Velthuis, Sebastiaan [VerfasserIn] |
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| | Lutgens, Esther [VerfasserIn] |
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| | Wijnands, Erwin [VerfasserIn] |
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| | Tschöpe, Carsten [VerfasserIn] |
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| | Schmuttermaier, Christina [VerfasserIn] |
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| | Kzhyshkowska, Julia [VerfasserIn] |
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| | Jones, Elizabeth Anne Vincent [VerfasserIn] |
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| | Heymans, Stephane [VerfasserIn] |
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| Titel: | Stabilin-1 mediates beneficial monocyte recruitment and tolerogenic macrophage programming during CVB3-induced viral myocarditis |
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| Verf.angabe: | Paolo Carai, Anna Pia Papageorgiou, Sophie Van Linthout, Sophie Deckx, Sebastiaan Velthuis, Esther Lutgens, Erwin Wijnands, Carsten Tschöpe, Christina Schmuttermaier, Julia Kzhyshkowska, Elizabeth Anne Vincent Jones, Stephane Heymans |
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| E-Jahr: | 2022 |
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| Jahr: | April 2022 |
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| Umfang: | 9 S. |
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| Fussnoten: | Online verfügbar: 28. Dezember 2021, Artikelversion: 30. Dezember 2021 ; Gesehen am 12.03.2024 |
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| Titel Quelle: | Enthalten in: Journal of molecular and cellular cardiology |
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| Ort Quelle: | New York, NY [u.a.] : Elsevier, 1970 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 165(2022) vom: Apr., Seite 31-39 |
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| ISSN Quelle: | 1095-8584 |
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| Abstract: | Pathological innate and adaptive immune response upon viral infection may lead to cardiac injury and dysfunction. Stabilin-1 is a scavenger receptor that regulates several aspects of the innate immunity. Whether stabilin-1 affects the inflammatory response during viral myocarditis (VM) is entirely unknown. Here, we assess the role of stabilin-1 in the pathogenesis of VM and its suitability as a therapeutic target. Genetic loss of stabilin-1 increased mortality and cardiac necrosis in a mouse model of human Coxsackievirus B3 (CVB3)-induced myocarditis. Absence of stabilin-1 significantly reduced monocyte recruitment and strongly reduced the number of alternatively activated anti-inflammatory macrophages in the heart, enhancing a pro-inflammatory cardiac niche with a detrimental T lymphocyte response during VM. Yeast two-hybrid screening, confirmed by affinity chromatography, identified fibronectin as a stabilin-1 interacting partner. Absence of stabilin-1 specifically decreased monocyte adhesion on extracellular fibronectin in vitro. Loss of Type III repeats Extra Domain A (EDA) of fibronectin during VM also increased the mortality and cardiac necrosis as in stabilin-1 knockout mice, with reduced monocytic cardiac recruitment and increased T lymphocyte response. Collectively, stabilin-1 has an immune-suppressive role of limiting myocardial damage during VM, regulating anti-inflammatory monocyte-recruitment to the site of inflammation. |
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| DOI: | doi:10.1016/j.yjmcc.2021.12.009 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.yjmcc.2021.12.009 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0022282821002364 |
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| | DOI: https://doi.org/10.1016/j.yjmcc.2021.12.009 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Fibronectin |
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| | Inflammation |
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| | Monocytes |
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| | Stabilin-1 |
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| | Viral myocarditis |
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| K10plus-PPN: | 1883172101 |
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| Verknüpfungen: | → Zeitschrift |
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Stabilin-1 mediates beneficial monocyte recruitment and tolerogenic macrophage programming during CVB3-induced viral myocarditis / Carai, Paolo [VerfasserIn]; April 2022 (Online-Ressource)
