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Status: Bibliographieeintrag

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Verfasst von:Giesen, Alexander [VerfasserIn]   i
 Mouselimis, Dimitrios [VerfasserIn]   i
 Weichsel, Loris [VerfasserIn]   i
 Giannopoulos, Andreas A. [VerfasserIn]   i
 Schmermund, Axel [VerfasserIn]   i
 Nunninger, Maximilian Martin [VerfasserIn]   i
 Schütz, Moritz [VerfasserIn]   i
 André, Florian [VerfasserIn]   i
 Frey, Norbert [VerfasserIn]   i
 Korosoglou, Grigorios [VerfasserIn]   i
Titel:Pericoronary adipose tissue attenuation is associated with non-calcified plaque burden in patients with chronic coronary syndromes
Verf.angabe:Alexander Giesen, Dimitrios Mouselimis, Loris Weichsel, Andreas A. Giannopoulos, Axel Schmermund, Max Nunninger, Moritz Schuetz, Florian André, Norbert Frey, Grigorios Korosoglou
E-Jahr:2023
Jahr:November-December 2023
Umfang:9 S.
Illustrationen:Illustrationen
Fussnoten:Online verfügbar: 31, August 2023, Artikelversion: 18. Dezember 2023 ; Gesehen am 12.03.2024
Titel Quelle:Enthalten in: Journal of cardiovascular computed tomography
Ort Quelle:Amsterdam [u.a.] : Elsevier, 2007
Jahr Quelle:2023
Band/Heft Quelle:17(2023), 6, Seite 384-392
ISSN Quelle:1876-861X
Abstract:Background - Pericoronary adipose tissue attenuation (PCAT) is a marker of inflammation of the pericoronary fat tissue, which can be assessed by coronary computed tomography angiography (CCTA). Its prognostic value was reported in previous studies. Nevertheless, the relationship between PCAT, plaque burden and coronary artery disease (CAD) severity, are not well defined. - Aim - We sought to evaluate the relationship between PCAT, CAD severity based on the CAD-RADS 2.0 score and plaque burden in patients with chronic coronary syndrome (CCS). - Methods - Consecutive patients with a clinical indication for CCTA due to suspected or known CCS were included in our study. PCAT was measured in the proximal 4 ​cm of each of the right coronary artery (RCA), left anterior descending artery (LAD), and the left circumflex artery (LCX). The CAD-RADS 2.0 score was assessed in all patients and total, calcified, and non-calcified plaque burden was quantitatively measured. - Results - 868 patients (median age of 67.0 (IQR ​= ​58.0-75.0)yrs., 400 (46.1%) female) underwent CCTA between September 2020 and August 2022 due to CCS. Weak correlations were found between PCAT and the total plaque burden, as well as with the Agatston score, whereas no correlations were found between PCAT and CAD-RADS 2.0 score. Associations were also observed between the PCAT of the LAD, RCA and LCX with non-calcified plaque burden (Odds ratios of 1.22 (95%CI ​= ​1.15-1.29), 1.11 (95%CI ​= ​1.07-1.17) and 1.14 (95%CI ​= ​1.08-1.14), respectively, p ​< ​0.001 for all) which were independent of age, the Agatston score, and the CAD-RADS 2.0 score). In addition, higher PCAT were noticed with increasing number of plaques, exhibiting high-risk features per patient (p ​< ​0.05 by ANOVA for all). - Conclusion - PCAT exhibits significant associations with non-calcified plaque burden and plaques with high-risk features in patients undergoing CCTA for CCS. Thus, PCAT may identify high-risk patients who could benefit from more aggressive preventive therapy, which merits further investigation in future studies.
DOI:doi:10.1016/j.jcct.2023.08.008
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.jcct.2023.08.008
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S193459252300415X
 DOI: https://doi.org/10.1016/j.jcct.2023.08.008
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:CAD-RADS 2.0
 Coronary artery disease
 Pericoronary adipose tissue attenuation (PCAT)
 Total plaque burden
K10plus-PPN:1883182190
Verknüpfungen:→ Zeitschrift

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