Improved reproducibility for myocardial ASL

• Verfasst von: Božić-Iven, Maša [VerfasserIn]
• Verfasst von: Rapacchi, Stanislas [VerfasserIn]
• Verfasst von: Tao, Qian [VerfasserIn]
• Verfasst von: Pierce, Iain [VerfasserIn]
• Verfasst von: Thornton, George [VerfasserIn]
• Verfasst von: Nitsche, Christian [VerfasserIn]
• Verfasst von: Treibel, Thomas A. [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Verfasst von: Weingärtner, Sebastian [VerfasserIn]
• Titel: Improved reproducibility for myocardial ASL
• Titelzusatz: impact of physiological and acquisition parameters
• Verf.angabe: Maša Božić-Iven, Stanislas Rapacchi, Qian Tao, Iain Pierce, George Thornton, Christian Nitsche, Thomas A. Treibel, Lothar R. Schad, Sebastian Weingärtner
• E-Jahr: 2024
• Jahr: January 2024
• Umfang: 15 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht: 5. September 2023 ; Gesehen am 12.03.2024
• Titel Quelle: Enthalten in: Magnetic resonance in medicine
• Ort Quelle: New York, NY [u.a.] : Wiley-Liss, 1984
• Jahr Quelle: 2024
• Band/Heft Quelle: 91(2024), 1 vom: Jan., Seite 118-132
• ISSN Quelle: 1522-2594
• DOI: doi:10.1002/mrm.29834
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cardiac arterial spin labeling
• Sach-SW: cardiac magnetic resonance imaging
• Sach-SW: flow-sensitive alternating inversion recovery
• Sach-SW: myocardial blood flow
• K10plus-PPN: 1883184568

Abstract

Purpose To investigate and mitigate the influence of physiological and acquisition-related parameters on myocardial blood flow (MBF) measurements obtained with myocardial Arterial Spin Labeling (myoASL). Methods A Flow-sensitive Alternating Inversion Recovery (FAIR) myoASL sequence with bSSFP and spoiled GRE (spGRE) readout is investigated for MBF quantification. Bloch-equation simulations and phantom experiments were performed to evaluate how variations in acquisition flip angle (FA), acquisition matrix size (AMS), heart rate (HR) and blood T1\ \mathrmT_1 \ relaxation time (T1,B\ \mathrmT_1,B \) affect quantification of myoASL-MBF. In vivo myoASL-images were acquired in nine healthy subjects. A corrected MBF quantification approach was proposed based on subject-specific T1,B\ \mathrmT_1,B \ values and, for spGRE imaging, subtracting an additional saturation-prepared baseline from the original baseline signal. Results Simulated and phantom experiments showed a strong dependence on AMS and FA (R2\ R^2 \>0.73), which was eliminated in simulations and alleviated in phantom experiments using the proposed saturation-baseline correction in spGRE. Only a very mild HR dependence (R2\ R^2 \>0.59) was observed which was reduced when calculating MBF with individual T1,B\ \mathrmT_1,B \. For corrected spGRE, in vivo mean global spGRE-MBF ranged from 0.54 to 2.59 mL/g/min and was in agreement with previously reported values. Compared to uncorrected spGRE, the intra-subject variability within a measurement (0.60 mL/g/min), between measurements (0.45 mL/g/min), as well as the inter-subject variability (1.29 mL/g/min) were improved by up to 40% and were comparable with conventional bSSFP. Conclusion Our results show that physiological and acquisition-related factors can lead to spurious changes in myoASL-MBF if not accounted for. Using individual T1,B\ \mathrmT_1,B \ and a saturation-baseline can reduce these variations in spGRE and improve reproducibility of FAIR-myoASL against acquisition parameters.