Pooled analysis of complications with transvenous ICD compared to subcutaneous ICD in patients with catecholaminergic polymorphic ventricular arrhythmia

• Verfasst von: Eckert, Henrik [VerfasserIn]
• Verfasst von: El-Battrawy, Ibrahim [VerfasserIn]
• Verfasst von: Veith, Michael [VerfasserIn]
• Verfasst von: Roterberg, Gretje [VerfasserIn]
• Verfasst von: Kowitz, Jacqueline [VerfasserIn]
• Verfasst von: Lang, Siegfried [VerfasserIn]
• Verfasst von: Zhou, Xiao-Bo [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Verfasst von: Mügge, Andreas [VerfasserIn]
• Verfasst von: Aweimer, Assem [VerfasserIn]
• Titel: Pooled analysis of complications with transvenous ICD compared to subcutaneous ICD in patients with catecholaminergic polymorphic ventricular arrhythmia
• Verf.angabe: Henrik Eckert, Ibrahim El-Battrawy, Michael Veith, Gretje Roterberg, Jacqueline Kowitz, Siegfried Lang, Xiaobo Zhou, Ibrahim Akin, Andreas Mügge and Assem Aweimer
• E-Jahr: 2022
• Jahr: 28 March 2022
• Umfang: 9 S.
• Fussnoten: Gesehen am 18.03.2024
• Titel Quelle: Enthalten in: Journal of Personalized Medicine
• Ort Quelle: Basel : MDPI, 2011
• Jahr Quelle: 2022
• Band/Heft Quelle: 12(2022), 4, Artikel-ID 536, Seite 1-9
• ISSN Quelle: 2075-4426
• DOI: doi:10.3390/jpm12040536
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: catecholaminergic polymorphic ventricular tachycardia
• Sach-SW: ICD-complications
• Sach-SW: subcutaneous defibrillator
• Sach-SW: sudden cardiac death
• K10plus-PPN: 1883666562

Abstract

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is associated with arrhythmic events which may lead to sudden cardiac death (SCD). A leading therapy for CPVT besides medical treatment with beta-blockers is the use of an implantable cardioverter-defibrillator (ICD). For this paper we compared data from a pooled analysis to get further evidence about the complications of transvenous and subcutaneous ICDs. Methods: We gathered data from a search of PubMed, Web of Science, Cochrane Library and Cinahl. For our analysis, we chose 30 studies with a total number of 784 patients. We compared the data regarding complications caused by different ICD device types. Results: During a mean follow up of 38.9 months for the patients with ICD implantation (n = 337), data showed a complication rate of 101 (30%). A total of 330 (98%) of them received a transvenous-ICD (T-ICD) and 7 (2%) a subcutaneous-ICD (S-ICD). A total of 97 (29.4%) of the T-ICD patients and 4 (57.1%) of the S-ICD patients had at least one complication. Of the 234 complications that occurred in T-ICD patients 152 (65%) were inappropriate shocks due to supraventricular arrhythmias, T/R-wave oversensing or electrode defect, 26 (11.1%) lead fracture/failure, 1 (0.4%) electrode defect, 46 were (19.7%) events of electrical storms, 1 (0.4%) thromboembolic event, 2 (0.8%) cases of endocarditis and 6 (2.6%) infections of the ICD-pocket. Ten (100%) of the complications for the four patients with the S-ICD were an event of an inappropriate shock due to supraventricular arrhythmias, T/R-wave oversensing or electrode defect. Conclusion: Subcutaneous ICDs (S-ICD) show a certain advantage over T-ICDs regarding lead-related complications. Nevertheless, they still show problems with inappropriate shocks and other ICD related complications. Therefore, a case-by-case decision is advised, but the continuous improvement of S-ICD might make it an overall advantageous therapy option in the future.