Status: Bibliographieeintrag
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| Verfasst von: | Birgin, Emrullah [VerfasserIn]  |
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| | Hetjens, Svetlana [VerfasserIn] |
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| | Tam, Moses [VerfasserIn] |
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| | Correa-Gallego, Camilo [VerfasserIn] |
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| | Rahbari, Nuh Nabi [VerfasserIn] |
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| Titel: | Stereotactic body radiation therapy versus surgical resection for stage I/II hepatocellular carcinoma |
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| Verf.angabe: | Emrullah Birgin, Svetlana Hetjens, Moses Tam, Camilo Correa-Gallego and Nuh N. Rahbari |
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| E-Jahr: | 2023 |
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| Jahr: | 17 April 2023 |
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| Umfang: | 14 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 19.03.2024 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 15(2023), 8, Seite 1-14 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | SBRT is an emerging locoregional treatment modality for hepatocellular carcinoma (HCC). Although local tumor control rates seem encouraging, large-scale survival data comparing SBRT to surgical resection are lacking. We identified patients with stage I/II HCC from the National Cancer Database amenable for potential surgical resection. Patients undergoing hepatectomy were matched by propensity score (1:2) with patients who underwent SBRT as primary treatment. A total of 3787 (91%) and 366 (9%) patients underwent surgical resection or SBRT between 2004 and 2015, respectively. After propensity matching, the 5-year overall survival was 24% (95% CI 19-30%) in the SBRT group versus 48% (95% CI 43-53%) in the surgery group (p < 0.001). The association of surgery with overall survival was consistent in all subgroups. In patients treated with SBRT, a biologic effective dose (BED) of ≥100 Gy (31%, 95% CI 22%-40%) compared with BED < 100 Gy (13%, 95% CI 8-22%) was associated with a higher 5-year overall survival rate (hazard ratio of mortality of 0.58, 95% CI 0.43-0.77; p < 0.001). Surgical resection may be associated with prolonged overall survival compared with SBRT in patients with stage I/II HCC. |
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| DOI: | doi:10.3390/cancers15082330 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers15082330 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/15/8/2330 |
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| | DOI: https://doi.org/10.3390/cancers15082330 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ablative 4 |
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| | HCC 5 |
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| | liver resection 2 |
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| | multimodal 3 |
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| | SBRT 1 |
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| K10plus-PPN: | 1883748054 |
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| Verknüpfungen: | → Zeitschrift |
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Stereotactic body radiation therapy versus surgical resection for stage I/II hepatocellular carcinoma / Birgin, Emrullah [VerfasserIn]; 17 April 2023 (Online-Ressource)
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