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Status: Bibliographieeintrag

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Verfasst von:Sommerer, Claudia [VerfasserIn]   i
 Müller-Krebs, Sandra [VerfasserIn]   i
 Nadal, Jennifer [VerfasserIn]   i
 Schultheiß, Ulla Teresa [VerfasserIn]   i
 Friedrich, Nele [VerfasserIn]   i
 Nauck, Matthias [VerfasserIn]   i
 Schmid, Matthias [VerfasserIn]   i
 Nußhag, Christian [VerfasserIn]   i
 Reiser, Jochen [VerfasserIn]   i
 Eckardt, Kai-Uwe [VerfasserIn]   i
 Zeier, Martin [VerfasserIn]   i
 Hayek, Salim [VerfasserIn]   i
Titel:Prospective cohort study of soluble urokinase plasminogen activation receptor and cardiovascular events in patients with CKD
Verf.angabe:Claudia Sommerer, Sandra Müller-Krebs, Jennifer Nadal, Ulla T. Schultheiss, Nele Friedrich, Matthias Nauck, Matthias Schmid, Christian Nußhag, Jochen Reiser, Kai-Uwe Eckardt, Martin Zeier and Salim S. Hayek on behalf of the German Chronic Kidney Disease Investigators
E-Jahr:2023
Jahr:9 September 2023
Umfang:11 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 19.3.2024
Titel Quelle:Enthalten in: Kidney international. Reports
Ort Quelle:Amsterdam : Elsevier, 2016
Jahr Quelle:2023
Band/Heft Quelle:8(2023), 11 vom: Nov., Seite 2265-2275
ISSN Quelle:2468-0249
Abstract:Introduction - Soluble urokinase plasminogen activation receptor (suPAR) is an immune-derived pathogenic factor for kidney and atherosclerotic disease. Whether the association between suPAR and cardiovascular (CV) outcomes is dependent on the severity of underlying kidney disease is unclear. - Methods - We measured serum suPAR levels in 4994 participants (mean age 60 years; 60% men; 36% with diabetes mellitus; mean estimated glomerular filtration rate (eGFR) 49 ml/min per 1.73 m2, SD 18) of the German Chronic Kidney Disease (GCKD) cohort and examined its association with all-cause death, CV death, and major CV events (MACE) across the range of eGFR and urine albumin-to-creatinine ratio (UACR). - Results - The median suPAR level was 1771 pg/ml (interquartile range [IQR] 1447-2254 pg/ml). SuPAR levels were positively and independently correlated with age, eGFR, UACR, and parathyroid hormone levels. There were 573 deaths, including 190 CV deaths and 683 MACE events at a follow-up time of 6.5 years. In multivariable analyses, suPAR levels (log2) were associated with all-cause death (hazard ratio [HR] 1.36, 95% confidence interval [CI] 1.21-1.53), CV death (HR 1.27, 95% CI 1.03-1.57), and MACE (HR 1.13, 95% CI 1.00-1.28), and were not found to differ according to diabetes mellitus status, baseline eGFR, UACR, or parathyroid hormone levels. In mediation analysis, suPAR’s direct effect on all-cause death, CV death, and MACE accounted for 77%, 67%, and 60% of the total effect, respectively; whereas the effect mediated through eGFR accounted for 23%, 34%, and 40%, respectively. - Conclusion - In a large cohort of individuals with chronic kidney disease (CKD), suPAR levels were associated with mortality and CV outcomes independently of indices of kidney function, consistent with its independent role in the pathogenesis of atherosclerosis.
DOI:doi:10.1016/j.ekir.2023.08.038
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.ekir.2023.08.038
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2468024923014754
 DOI: https://doi.org/10.1016/j.ekir.2023.08.038
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:biomarkers
 cardiovascular outcomes
 cohort
 eGFR
 suPAR
 uACR
K10plus-PPN:1883749301
Verknüpfungen:→ Zeitschrift

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