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Status: Bibliographieeintrag

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Verfasst von:Bröcker, Martina [VerfasserIn]   i
 Simon, Dietmar [VerfasserIn]   i
 Fries, Mirka [VerfasserIn]   i
 Kornely, Elisabeth [VerfasserIn]   i
 Weber, Manuel [VerfasserIn]   i
 Vardarli, Irfan [VerfasserIn]   i
 Gilman, Elena [VerfasserIn]   i
 Herrmann, Ken [VerfasserIn]   i
 Görges, Rainer [VerfasserIn]   i
Titel:Update on calcitonin screening for medullary thyroid carcinoma and the results of a retrospective analysis of 12,984 patients with thyroid nodules
Verf.angabe:Martina Broecker-Preuss, Dietmar Simon, Mirka Fries, Elisabeth Kornely, Manuel Weber, Irfan Vardarli, Elena Gilman, Ken Herrmann and Rainer Görges
E-Jahr:2023
Jahr:17 April 2023
Umfang:20 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 19.03.2024
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2023
Band/Heft Quelle:15(2023), 8, Seite 1-20
ISSN Quelle:2072-6694
Abstract:Background: We provide an update on calcitonin (Ctn) screening for the early detection of medullary thyroid carcinoma (MTC) and present the results of a large single-center analysis evaluating sex-specific cut-off-levels and long-term courses. Methods: A total of 12,984 consecutive adult patients (20.1% male and 79.9% female) with thyroid nodules who had undergone routine Ctn measurement were retrospectively analyzed. Patients with confirmed suspicious Ctn values were referred for surgery. Results: Ctn measurements were elevated in 207 (1.6%) patients, with values below twice the sex-specific reference limit in 82% of these cases. Further clarification was possible in 124/207 cases, of which MTC could be ruled out in 108 cases. Histopathological assessment confirmed MTC in 16/12,984 patients. Conclusions: Our extrapolated MTC prevalence of 0.14% is significantly lower than that described in early international screening studies. The stimulation test can usually be dispensable when using a decision-making concept based on sex-specific basal Ctn cut-off values. Ctn screening is recommended even in patients with very small thyroid nodules. High quality standards in pre-analytics, laboratory measurements, and the interpretation of data must be ensured, as well as close interdisciplinary cooperation between medical disciplines.
DOI:doi:10.3390/cancers15082333
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/cancers15082333
 kostenfrei: Volltext: https://www.mdpi.com/2072-6694/15/8/2333
 DOI: https://doi.org/10.3390/cancers15082333
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:calcitonin
 calcitonin screening
 calcium stimulation test
 medullary thyroid cancer
 nodular thyroid disease
 routine calcitonin measurement
K10plus-PPN:188378476X
Verknüpfungen:→ Zeitschrift

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