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| Verfasst von: | Bröcker, Martina [VerfasserIn]  |
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| | Simon, Dietmar [VerfasserIn] |
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| | Fries, Mirka [VerfasserIn] |
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| | Kornely, Elisabeth [VerfasserIn] |
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| | Weber, Manuel [VerfasserIn] |
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| | Vardarli, Irfan [VerfasserIn] |
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| | Gilman, Elena [VerfasserIn] |
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| | Herrmann, Ken [VerfasserIn] |
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| | Görges, Rainer [VerfasserIn] |
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| Titel: | Update on calcitonin screening for medullary thyroid carcinoma and the results of a retrospective analysis of 12,984 patients with thyroid nodules |
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| Verf.angabe: | Martina Broecker-Preuss, Dietmar Simon, Mirka Fries, Elisabeth Kornely, Manuel Weber, Irfan Vardarli, Elena Gilman, Ken Herrmann and Rainer Görges |
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| E-Jahr: | 2023 |
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| Jahr: | 17 April 2023 |
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| Umfang: | 20 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 19.03.2024 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 15(2023), 8, Seite 1-20 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Background: We provide an update on calcitonin (Ctn) screening for the early detection of medullary thyroid carcinoma (MTC) and present the results of a large single-center analysis evaluating sex-specific cut-off-levels and long-term courses. Methods: A total of 12,984 consecutive adult patients (20.1% male and 79.9% female) with thyroid nodules who had undergone routine Ctn measurement were retrospectively analyzed. Patients with confirmed suspicious Ctn values were referred for surgery. Results: Ctn measurements were elevated in 207 (1.6%) patients, with values below twice the sex-specific reference limit in 82% of these cases. Further clarification was possible in 124/207 cases, of which MTC could be ruled out in 108 cases. Histopathological assessment confirmed MTC in 16/12,984 patients. Conclusions: Our extrapolated MTC prevalence of 0.14% is significantly lower than that described in early international screening studies. The stimulation test can usually be dispensable when using a decision-making concept based on sex-specific basal Ctn cut-off values. Ctn screening is recommended even in patients with very small thyroid nodules. High quality standards in pre-analytics, laboratory measurements, and the interpretation of data must be ensured, as well as close interdisciplinary cooperation between medical disciplines. |
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| DOI: | doi:10.3390/cancers15082333 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers15082333 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/15/8/2333 |
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| | DOI: https://doi.org/10.3390/cancers15082333 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | calcitonin |
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| | calcitonin screening |
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| | calcium stimulation test |
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| | medullary thyroid cancer |
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| | nodular thyroid disease |
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| | routine calcitonin measurement |
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| K10plus-PPN: | 188378476X |
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| Verknüpfungen: | → Zeitschrift |
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Update on calcitonin screening for medullary thyroid carcinoma and the results of a retrospective analysis of 12,984 patients with thyroid nodules / Bröcker, Martina [VerfasserIn]; 17 April 2023 (Online-Ressource)
