| Online-Ressource |
Verfasst von: | Bröcker, Martina [VerfasserIn]  |
| Simon, Dietmar [VerfasserIn]  |
| Fries, Mirka [VerfasserIn]  |
| Kornely, Elisabeth [VerfasserIn]  |
| Weber, Manuel [VerfasserIn]  |
| Vardarli, Irfan [VerfasserIn]  |
| Gilman, Elena [VerfasserIn]  |
| Herrmann, Ken [VerfasserIn]  |
| Görges, Rainer [VerfasserIn]  |
Titel: | Update on calcitonin screening for medullary thyroid carcinoma and the results of a retrospective analysis of 12,984 patients with thyroid nodules |
Verf.angabe: | Martina Broecker-Preuss, Dietmar Simon, Mirka Fries, Elisabeth Kornely, Manuel Weber, Irfan Vardarli, Elena Gilman, Ken Herrmann and Rainer Görges |
E-Jahr: | 2023 |
Jahr: | 17 April 2023 |
Umfang: | 20 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 19.03.2024 |
Titel Quelle: | Enthalten in: Cancers |
Ort Quelle: | Basel : MDPI, 2009 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 15(2023), 8, Seite 1-20 |
ISSN Quelle: | 2072-6694 |
Abstract: | Background: We provide an update on calcitonin (Ctn) screening for the early detection of medullary thyroid carcinoma (MTC) and present the results of a large single-center analysis evaluating sex-specific cut-off-levels and long-term courses. Methods: A total of 12,984 consecutive adult patients (20.1% male and 79.9% female) with thyroid nodules who had undergone routine Ctn measurement were retrospectively analyzed. Patients with confirmed suspicious Ctn values were referred for surgery. Results: Ctn measurements were elevated in 207 (1.6%) patients, with values below twice the sex-specific reference limit in 82% of these cases. Further clarification was possible in 124/207 cases, of which MTC could be ruled out in 108 cases. Histopathological assessment confirmed MTC in 16/12,984 patients. Conclusions: Our extrapolated MTC prevalence of 0.14% is significantly lower than that described in early international screening studies. The stimulation test can usually be dispensable when using a decision-making concept based on sex-specific basal Ctn cut-off values. Ctn screening is recommended even in patients with very small thyroid nodules. High quality standards in pre-analytics, laboratory measurements, and the interpretation of data must be ensured, as well as close interdisciplinary cooperation between medical disciplines. |
DOI: | doi:10.3390/cancers15082333 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers15082333 |
| kostenfrei: Volltext: https://www.mdpi.com/2072-6694/15/8/2333 |
| DOI: https://doi.org/10.3390/cancers15082333 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | calcitonin |
| calcitonin screening |
| calcium stimulation test |
| medullary thyroid cancer |
| nodular thyroid disease |
| routine calcitonin measurement |
K10plus-PPN: | 188378476X |
Verknüpfungen: | → Zeitschrift |
Update on calcitonin screening for medullary thyroid carcinoma and the results of a retrospective analysis of 12,984 patients with thyroid nodules / Bröcker, Martina [VerfasserIn]; 17 April 2023 (Online-Ressource)