| |  Online-Ressource |
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| Verfasst von: | Perna, Laura [VerfasserIn]  |
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| | Zhang, Yan [VerfasserIn] |
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| | Wild, Beate [VerfasserIn] |
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| | Kliegel, Matthias [VerfasserIn] |
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| | Ihle, Andreas [VerfasserIn] |
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| | Schöttker, Ben [VerfasserIn] |
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| | Mons, Ute [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| Titel: | Childhood exposure to hunger |
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| Titelzusatz: | associations with health outcomes in later life and epigenetic markers |
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| Verf.angabe: | Laura Perna, Yan Zhang, Beate Wild, Matthias Kliegel, Andreas Ihle, Ben Schöttker, Ute Mons, Hermann Brenner |
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| E-Jahr: | 2020 |
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| Jahr: | 20 Nov 2020 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 22.03.2024 |
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| Titel Quelle: | Enthalten in: Epigenomics |
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| Ort Quelle: | London : Future Medicine Ltd., 2009 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 12(2020), 21, Seite 1861-1870 |
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| ISSN Quelle: | 1750-192X |
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| Abstract: | Aim: To assess associations of early exposure to hunger with depressive symptoms and cardiovascular disease (CVD) and to investigate possible epigenetic pathways. Patients & methods: Data were based on a German population-based cohort of older adults (n = 9631). Regression models were performed for health outcomes in later life. An epigenome-wide association study for early-life exposure to hunger was performed in a subgroup (n = 2221) with whole blood DNA methylation data. Results: Childhood exposure to hunger was associated with CVD and depressive symptoms in later life. Prenatal or infant exposure was strongly associated with depressive symptoms. No CpG reached epigenome-wide significance after multiple testing correction. Conclusion: Childhood hunger is a risk factor for depressive symptoms and CVD at older age. DNA methylation could not explain this association. |
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| DOI: | doi:10.2217/epi-2019-0333 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.2217/epi-2019-0333 |
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| | Volltext: https://www.futuremedicine.com/doi/10.2217/epi-2019-0333 |
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| | DOI: https://doi.org/10.2217/epi-2019-0333 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cardiovascular disease |
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| | childhood hunger |
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| | depressive symptoms |
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| | DNA methylation |
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| | early-life adversity |
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| | epigenetics |
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| | EWAS |
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| | German famine |
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| | late-life depression |
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| | older adults |
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| K10plus-PPN: | 1884060102 |
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| Verknüpfungen: | → Zeitschrift |
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Childhood exposure to hunger / Perna, Laura [VerfasserIn]; 20 Nov 2020 (Online-Ressource)
