| |  Online-Ressource |
|---|
| Verfasst von: | Neuberger, Manuel [VerfasserIn]  |
|---|
| | Skladny, Janina [VerfasserIn] |
|---|
| | Goly, Nora [VerfasserIn] |
|---|
| | Wessels, Frederik [VerfasserIn] |
|---|
| | Weiß, Christel [VerfasserIn] |
|---|
| | Egen, Luisa [VerfasserIn] |
|---|
| | Erben, Philipp [VerfasserIn] |
|---|
| | Groß-Weege, Matthias [VerfasserIn] |
|---|
| | Grüne, Britta [VerfasserIn] |
|---|
| | Hartung, Friedrich [VerfasserIn] |
|---|
| | Herrmann, Jonas [VerfasserIn] |
|---|
| | Honeck, Patrick [VerfasserIn] |
|---|
| | Jarczyk, Jonas [VerfasserIn] |
|---|
| | Kowalewski, Karl-Friedrich [VerfasserIn] |
|---|
| | Mühlbauer, Julia [VerfasserIn] |
|---|
| | Nitschke, Katja [VerfasserIn] |
|---|
| | Nientiedt, Malin [VerfasserIn] |
|---|
| | Walach, Margarete [VerfasserIn] |
|---|
| | Waldbillig, Frank [VerfasserIn] |
|---|
| | Westhoff, Niklas Christian [VerfasserIn] |
|---|
| | Hardenberg, Jost von [VerfasserIn] |
|---|
| | Kriegmair, Maximilian [VerfasserIn] |
|---|
| | Worst, Thomas [VerfasserIn] |
|---|
| | Nuhn, Philipp [VerfasserIn] |
|---|
| Titel: | Baseline modified Glasgow Prognostic Score (mGPS) predicts radiologic response and overall survival in metastatic hormone-sensitive prostate cancer treated with docetaxel chemotherapy |
|---|
| Verf.angabe: | Manuel Neuberger, Janina Skladny, Nora Goly, Frederik Wessels, Christel Weiß, Luisa Egen, Philipp Erben, Matthias Groß-Weege, Britta Grüne, Friedrich Hartung, Jonas Herrmann, Patrick Honeck, Jonas Jarczyk, Karl-Friedrich Kowalewski, Julia Mühlbauer, Katja Nitschke, Malin Nientiedt, Margarete Theresa Walach, Frank Waldbillig, Niklas Westhoff, Jost von Hardenberg, Maximilian Kriegmair, Thomas S. Worst and Philipp Nuhn |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | April 2022 |
|---|
| Umfang: | 8 S. |
|---|
| Fussnoten: | Online veröffentlicht: 28. März 2022 ; Margarete Teresa Walach ist fälschlich als Margarete Theresa Walach geschrieben ; Gesehen am 25.03.2024 |
|---|
| Titel Quelle: | Enthalten in: Anticancer research |
|---|
| Ort Quelle: | Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 42(2022), 4 vom: Apr., Seite 1911-1918 |
|---|
| ISSN Quelle: | 1791-7530 |
|---|
| Abstract: | Background/Aim: To assess the baseline inflammatory markers modified Glasgow Prognostic Score (mGPS), systemic immune-inflammation index (SII), and neutrophile-to-lymphocyte ratio (NLR) as pragmatic tools for predicting response to chemohormonal therapy (docetaxel plus ADT) and prognosis in men with metastatic hormone-sensitive prostate cancer (mHSPC). Patients and Methods: Male patients who received docetaxel at a tertiary university care center between 2014 and 2019 were screened for completion of 6 cycles. NLR, SII, mGPS, overall survival (OS), three-year survival, and radiologic response were assessed. Complete response (CR), partial response (PR), and stable disease (SD) were analyzed alone and in combination. Results: Thirty-six mHSPC-patients were included. In thirty patients, baseline mGPS was assessed and was either 0 (n=22) or 2 (n=8). In Cochran-Armitage Trend Test, mGPS showed significant association with the combined radiologic endpoint of “CR, PR, or SD” (p=0.01), three-year survival (p=0.02), and OS (p<0.01). Next to prostate-specific antigen (PSA) (HR per 100 units 1.16, 95%CI=1.04-1.30, p<0.01), NLR (HR=1.31, 95%CI=1.03-1.66, p=0.03), and mGPS (2 vs. 0, HR=6.53, 95%CI=1.6-27.0, p<0.01) at baseline showed significant association with OS in univariable cox regression. However, mGPS remained the only independent predictor for OS in multivariable cox regression (p<0.01) and for the combined radiologic endpoint of “CR, PR or SD” (p=0.01) in multivariable logistic regression. SII showed no statistical relevance. Conclusion: Baseline mGPS seems to be a pragmatic tool for clinical decision-making in patients with mHSPC in daily routine. |
|---|
| DOI: | doi:10.21873/anticanres.15668 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.21873/anticanres.15668 |
|---|
| | Volltext: https://ar.iiarjournals.org/content/42/4/1911 |
|---|
| | DOI: https://doi.org/10.21873/anticanres.15668 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Biomarkers |
|---|
| | neutrophile-to-lymphocyte ratio |
|---|
| | overall survival |
|---|
| | prognosis |
|---|
| | systemic immune-inflammation index |
|---|
| K10plus-PPN: | 1884205097 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Baseline modified Glasgow Prognostic Score (mGPS) predicts radiologic response and overall survival in metastatic hormone-sensitive prostate cancer treated with docetaxel chemotherapy / Neuberger, Manuel [VerfasserIn]; April 2022 (Online-Ressource)
