Prevalence and associations of keratoconus among children, adults, and elderly in the population-based Ural eye studies

• Verfasst von: Bikbov, Mukharram [VerfasserIn]
• Verfasst von: Kazakbaeva, Gyulli M. [VerfasserIn]
• Verfasst von: Gilmanshin, Timur R. [VerfasserIn]
• Verfasst von: Iakupova, Ellina M. [VerfasserIn]
• Verfasst von: Fakhretdinova, Albina A. [VerfasserIn]
• Verfasst von: Tuliakova, Azaliia M. [VerfasserIn]
• Verfasst von: Panda-Jonas, Songhomitra [VerfasserIn]
• Verfasst von: Rusakova, Iuliia A. [VerfasserIn]
• Verfasst von: Gilemzianova, Leisan I. [VerfasserIn]
• Verfasst von: Khakimov, Dinar A. [VerfasserIn]
• Verfasst von: Miniazeva, Liana A. [VerfasserIn]
• Verfasst von: Usubov, Emin L. [VerfasserIn]
• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Titel: Prevalence and associations of keratoconus among children, adults, and elderly in the population-based Ural eye studies
• Verf.angabe: Mukharram M. Bikbov, MD, PhD, Gyulli M. Kazakbaeva, MD, Timur R. Gilmanshin, MD, Ellina M. Iakupova, MD, Albina A. Fakhretdinova, MD, Azaliia M. Tuliakova, MD, Songhomitra Panda-Jonas, MD, Iuliia A. Rusakova, MD, Leisan I. Gilemzianova, MD, Dinar A. Khakimov, MD, Liana A. Miniazeva, MD, Emin L. Usubov, MD, and Jost B. Jonas, MD
• E-Jahr: 2023
• Jahr: November-December 2023
• Umfang: 13 S.
• Illustrationen: Illustrationen
• Fussnoten: Elektronische Reproduktion der Druckausgabe ; Gesehen am 04.04.2024
• Titel Quelle: Enthalten in: Asia-Pacific journal of ophthalmology
• Ort Quelle: Riverwoods, Ill. : Wolters Kluwer Health, 2012
• Jahr Quelle: 2023
• Band/Heft Quelle: 12(2023), 6 vom: Nov./Dez., Seite 591-603
• ISSN Quelle: 2162-0989
• DOI: doi:10.1097/APO.0000000000000639
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Ergänzung zu: Tello, Alejandro: Discrepancies in reported prevalence rates of keratoconus in Russia, in: Asia-Pacific Journal of Ophthalmology
• Sach-SW: cornea thickness
• Sach-SW: keratoconus
• Sach-SW: keratometry
• Sach-SW: refractive myopia
• Sach-SW: Russia
• K10plus-PPN: 1885023979

Abstract

Purpose: - To estimate prevalence and associations of keratoconus in populations in Russia with an age from childhood to seniority. - Methods: - The study population consisted of the cohorts of 3 population-based studies performed in urban and rural areas within the same geographical region in Bashkortostan/Russia: the Ural Children Eye Study (UCES; age = 6-18 y; n = 4890), the Ural Eye and Medical Study (UEMS; age = >40 y; n = 5314), and the Ural Very Old Study (UVOS; age = >85 y; n = 651). Based on Scheimflug imaging, keratoconus was defined by a keratometric reading of ≥48 diopters (D) in any eye. - Results: - The mean maximal and minimal corneal refractive power increased from the UCES (43.58 ± 1.50 D and 42.70 ± 1.42 D, respectively) to the UEMS (44.26 ± 1.70 D and 43.61 ± 1.76 D, respectively) and to the UVOS (45.1 ± 1.72 D and 43.98 ± 1.68 D, respectively). Correspondingly, keratoconus prevalence increased from the UCES (42/4890; 0.086%; 95% CI = 0.060, 0.112) to the UEMS (112/5314; 2.11%; 95% CI = 1.72, 2.49) and to the UVOS (42/651; 6.45%; 95% CI = 4.56, 8.34). In the UCES, higher keratoconus prevalence was associated (multivariable analysis) with higher birth order [odds ratio (OR) = 2.34; 95% CI = 1.32, 4.15; P = 0.004], lower birth weight (OR = 0.99; 95% CI = 0.99, 0.99; P < 0.001), and shorter axial length (OR = 0.15; 95% CI = 0.08, 0.30; P < 0.001). In the UEMS, keratoconus prevalence correlated with shorter axial length (OR = 0.15; 95% CI = 0.10, 0.23; P < 0.001), larger corneal volume (OR = 1.17; 95% CI = 1.09, 1.25; P = 0.001), thicker lens (OR = 2.27; 95% CI = 1.06, 5.28; P = 0.04), cortical cataract degree (OR = 1.02; 95% CI = 1.01, 1.04; P = 0.01), and higher stage of age-related macular degeneration (OR = 1.65; 95% CI = 1.09, 2.51; P = 0.02). In the UVOS, keratoconus prevalence correlated with lower educational level (OR = 0.84; 95% CI = 0.71, 0.99; P = 0.04) and lower dynamometric handgrip force (OR = 0.92; 95% CI = 0.88, 0.97; P = 0.003). - Conclusions: - In this study on multiethnic groups from Russia, keratoconus prevalence increased from the pediatric group (0.09%) to the adult group (2.11%) and seniority group (6.45%), correlated mostly with biometric ocular parameters and was in all age groups statistically independent of most systemic parameters.