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Verfasst von:Manrique-Silva, Esperanza [VerfasserIn]   i
 David, Millán-Esteban [VerfasserIn]   i
 Maider, Aguerralde-Martin [VerfasserIn]   i
 García-Casado, Zaida [VerfasserIn]   i
 Moro, Ruggero [VerfasserIn]   i
 Requena, Celia [VerfasserIn]   i
 Través, Victor [VerfasserIn]   i
 Virós, Amaya [VerfasserIn]   i
 Kumar, Rajiv [VerfasserIn]   i
 Nagore, Eduardo [VerfasserIn]   i
Titel:Clinical, histological, and molecular differences in melanoma due to different TERT promoter mutations subtypes.
Titelzusatz:A retrospective cross-sectional study in 684 melanoma patients
Verf.angabe:Esperanza Manrique-Silva, Millán-Esteban David, Aguerralde-Martin Maider, Zaida García-Casado, Ruggero Moro, Celia Requena, Victor Través, Amaya Virós, Rajiv Kumar, Eduardo Nagore
E-Jahr:2024
Jahr:May 2024
Umfang:9 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 05.04.2024
Titel Quelle:Enthalten in: Pigment cell & melanoma research
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 2008
Jahr Quelle:2024
Band/Heft Quelle:37(2024), 3 vom: Mai, Seite 343-351
ISSN Quelle:1755-148X
Abstract:Differences in survival according to the pTERT mutation subtypes (−124C > T, −146C > T, and tandem −138_139CC > TT) have been observed. The present study aimed to describe the clinical as the histopathological and molecular cutaneous melanoma features according to the presence of the three most prevalent pTERT mutation subtypes (−124C > T, −146C > T, and tandem −138_139CC > TT). A retrospective cross-sectional study including 684 patients was designed, and a Partial Least-Squares Discriminant Analysis (PLS-DA) was performed. After the PSL-DA, it was observed that the tandem −138_139CC > TT subtype differs from the other subtypes. The model demonstrated that the −124C > T and the −138_139 CC > TT subtypes were associated with fast-growing melanomas (OR 0.5, CI 0.29-0.86, p = .012) and with Breslow >2 mm (OR 0.6, CI 0.37-0.97, p = .037), compared to the −146C > T mutation. Finally, the −124C > T appeared to be more associated with the presence of TILs (non-brisk) than the −146C > T (OR 0.6, CI 0.40-1.01, p = .05). These findings confirmed that the −124C > T and the tandem −138_139 CC > TT subtypes are both highly associated with the presence of features of aggressiveness; however, only the −124C > T was highly associated with TILs. This difference could explain the worse survival rate associated with the tandem −138_139CC > TT mutations.
DOI:doi:10.1111/pcmr.13155
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1111/pcmr.13155
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/pcmr.13155
 DOI: https://doi.org/10.1111/pcmr.13155
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:biomarkers
 genetics
 melanoma
 oncology
 translational research
K10plus-PPN:1885088663
Verknüpfungen:→ Zeitschrift

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