| |  Online-Ressource |
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| Verfasst von: | Funk, Maja C. [VerfasserIn]  |
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| | Gleixner, Jan G. [VerfasserIn] |
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| | Heigwer, Florian [VerfasserIn] |
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| | Vonficht, Dominik [VerfasserIn] |
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| | Valentini, Erica [VerfasserIn] |
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| | Aydin, Zeynep [VerfasserIn] |
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| | Tonin, Elena [VerfasserIn] |
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| | Del Prete, Stefania [VerfasserIn] |
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| | Mahara, Sylvia [VerfasserIn] |
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| | Throm, Yannick [VerfasserIn] |
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| | Hetzer, Jenny [VerfasserIn] |
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| | Heide, Danijela [VerfasserIn] |
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| | Stegle, Oliver [VerfasserIn] |
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| | Odom, Duncan T. [VerfasserIn] |
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| | Feldmann, Angelika [VerfasserIn] |
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| | Haas, Simon [VerfasserIn] |
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| | Heikenwalder, Mathias [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| Titel: | Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice |
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| Verf.angabe: | Maja C. Funk, Jan G. Gleixner, Florian Heigwer, Dominik Vonficht, Erica Valentini, Zeynep Aydin, Elena Tonin, Stefania Del Prete, Sylvia Mahara, Yannick Throm, Jenny Hetzer, Danijela Heide, Oliver Stegle, Duncan T. Odom, Angelika Feldmann, Simon Haas, Mathias Heikenwalder, and Michael Boutros |
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| E-Jahr: | 2023 |
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| Jahr: | 18 December 2023 |
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| Umfang: | 24 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 18. Dezember 2023, Artikelversion: 18. Dezember 2023 ; Gesehen am 08.04.2024 |
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| Titel Quelle: | Enthalten in: Developmental cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2001 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 58(2023), 24 vom: Dez., Seite 2914-2929 |
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| ISSN Quelle: | 1878-1551 |
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| Abstract: | Low-grade chronic inflammation is a hallmark of ageing, associated with impaired tissue function and disease development. However, how cell-intrinsic and -extrinsic factors collectively establish this phenotype, termed inflammaging, remains poorly understood. We addressed this question in the mouse intestinal epithelium, using mouse organoid cultures to dissect stem cell-intrinsic and -extrinsic sources of inflammaging. At the single-cell level, we found that inflammaging is established differently along the crypt-villus axis, with aged intestinal stem cells (ISCs) strongly upregulating major histocompatibility complex class II (MHC-II) genes. Importantly, the inflammaging phenotype was stably propagated by aged ISCs in organoid cultures and associated with increased chromatin accessibility at inflammation-associated loci in vivo and ex vivo, indicating cell-intrinsic inflammatory memory. Mechanistically, we show that the expression of inflammatory genes is dependent on STAT1 signaling. Together, our data identify that intestinal inflammaging in mice is promoted by a cell-intrinsic mechanism, stably propagated by ISCs, and associated with a disbalance in immune homeostasis. |
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| DOI: | doi:10.1016/j.devcel.2023.11.013 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.devcel.2023.11.013 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1534580723006111 |
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| | DOI: https://doi.org/10.1016/j.devcel.2023.11.013 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ageing |
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| | epigenetics |
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| | inflammaging |
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| | inflammation |
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| | interferon |
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| | intestinal epithelium |
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| | intestinal stem cells |
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| | intestine |
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| | ISC |
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| | single-cell analysis |
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| K10plus-PPN: | 1885262892 |
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| Verknüpfungen: | → Zeitschrift |
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Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice / Funk, Maja C. [VerfasserIn]; 18 December 2023 (Online-Ressource)
