| |  Online-Ressource |
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| Verfasst von: | Sacirbegovic, Faruk [VerfasserIn]  |
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| | Günther, Matthias [VerfasserIn] |
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| | Greco, Alessandro [VerfasserIn] |
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| | Zhao, Daqiang [VerfasserIn] |
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| | Wang, Xi [VerfasserIn] |
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| | Zhou, Meng [VerfasserIn] |
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| | Rosenberger, Sarah [VerfasserIn] |
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| | Oberbarnscheidt, Martin H. [VerfasserIn] |
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| | Held, Werner [VerfasserIn] |
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| | McNiff, Jennifer [VerfasserIn] |
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| | Jain, Dhanpat [VerfasserIn] |
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| | Höfer, Thomas [VerfasserIn] |
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| | Shlomchik, Warren D. [VerfasserIn] |
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| Titel: | Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells |
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| Verf.angabe: | Faruk Sacirbegovic, Matthias Günther, Alessandro Greco, Daqiang Zhao, Xi Wang, Meng Zhou, Sarah Rosenberger, Martin H. Oberbarnscheidt, Werner Held, Jennifer McNiff, Dhanpat Jain, Thomas Höfer, and Warren D. Shlomchik |
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| E-Jahr: | 2023 |
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| Jahr: | 14 February 2023 |
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| Umfang: | 23 S. |
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| Fussnoten: | Online verfügbar 30 January 2023, Version des Artikels 14 February 2023 ; Gesehen am 10.04.2024 |
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| Titel Quelle: | Enthalten in: Immunity |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1994 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 56(2023), 2 vom: Feb., Seite 369-385, e1-e6 |
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| ISSN Quelle: | 1097-4180 |
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| Abstract: | In allogeneic hematopoietic stem cell transplantation, donor αβ T cells attack recipient tissues, causing graft-versus-host disease (GVHD), a major cause of morbidity and mortality. A central question has been how GVHD is sustained despite T cell exhaustion from chronic antigen stimulation. The current model for GVHD holds that disease is maintained through the continued recruitment of alloreactive effectors from blood into affected tissues. Here, we show, using multiple approaches including parabiosis of mice with GVHD, that GVHD is instead primarily maintained locally within diseased tissues. By tracking 1,203 alloreactive T cell clones, we fitted a mathematical model predicting that within each tissue a small number of progenitor T cells maintain a larger effector pool. Consistent with this, we identified a tissue-resident TCF-1+ subpopulation that preferentially engrafted, expanded, and differentiated into effectors upon adoptive transfer. These results suggest that therapies targeting affected tissues and progenitor T cells within them would be effective. |
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| DOI: | doi:10.1016/j.immuni.2023.01.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.immuni.2023.01.003 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1074761323000134 |
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| | DOI: https://doi.org/10.1016/j.immuni.2023.01.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | allogeneic hematopoietic stem cell transplantation |
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| | computational modeling |
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| | graft-versus-host disease |
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| | mouse models |
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| | parabiosis |
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| | single-cell RNA sequencing |
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| | T cell exhaustion |
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| | TCF-1 |
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| | TCF-7 |
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| | Tpex |
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| K10plus-PPN: | 1885466722 |
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| Verknüpfungen: | → Zeitschrift |
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Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells / Sacirbegovic, Faruk [VerfasserIn]; 14 February 2023 (Online-Ressource)
