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| Verfasst von: | Xiang, Shitong [VerfasserIn]  |
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| | Jia, Tianye [VerfasserIn] |
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| | Xie, Chao [VerfasserIn] |
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| | Cheng, Wei [VerfasserIn] |
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| | Chaarani, Bader [VerfasserIn] |
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| | Banaschewski, Tobias [VerfasserIn] |
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| | Barker, Gareth J. [VerfasserIn] |
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| | Bokde, Arun L. W. [VerfasserIn] |
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| | Büchel, Christian [VerfasserIn] |
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| | Desrivières, Sylvane [VerfasserIn] |
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| | Flor, Herta [VerfasserIn] |
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| | Grigis, Antoine [VerfasserIn] |
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| | Gowland, Penny A. [VerfasserIn] |
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| | Brühl, Rüdiger [VerfasserIn] |
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| | Martinot, Jean-Luc [VerfasserIn] |
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| | Martinot, Marie-Laure Paillère [VerfasserIn] |
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| | Nees, Frauke [VerfasserIn] |
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| | Orfanos, Dimitri Papadopoulos [VerfasserIn] |
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| | Poustka, Luise [VerfasserIn] |
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| | Hohmann, Sarah [VerfasserIn] |
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| | Fröhner, Juliane [VerfasserIn] |
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| | Smolka, Michael [VerfasserIn] |
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| | Vaidya, Nilakshi [VerfasserIn] |
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| | Walter, Henrik [VerfasserIn] |
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| | Whelan, Robert [VerfasserIn] |
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| | Garavan, Hugh [VerfasserIn] |
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| | Schumann, Gunter [VerfasserIn] |
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| | Sahakian, Barbara J. [VerfasserIn] |
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| | Robbins, Trevor W. [VerfasserIn] |
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| | Feng, Jianfeng [VerfasserIn] |
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| Titel: | Association between vmPFC gray matter volume and smoking initiation in adolescents |
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| Verf.angabe: | Shitong Xiang, Tianye Jia, Chao Xie, Wei Cheng, Bader Chaarani, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Christian Büchel, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny A. Gowland, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Hugh Garavan, Gunter Schumann, Barbara J. Sahakian, Trevor W. Robbins & Jianfeng Feng |
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| E-Jahr: | 2023 |
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| Jahr: | 15 August 2023 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 11.04.2024 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 14(2023), Artikel-ID 4684, Seite 1-13 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment. |
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| DOI: | doi:10.1038/s41467-023-40079-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-023-40079-2 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-023-40079-2 |
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| | DOI: https://doi.org/10.1038/s41467-023-40079-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Addiction |
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| | Cognitive neuroscience |
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| | Genetics of the nervous system |
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| | Predictive markers |
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| K10plus-PPN: | 1885585195 |
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| Verknüpfungen: | → Zeitschrift |
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Association between vmPFC gray matter volume and smoking initiation in adolescents / Xiang, Shitong [VerfasserIn]; 15 August 2023 (Online-Ressource)
