| |  Online-Ressource |
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| Verfasst von: | Ho, Kim Hoa [VerfasserIn]  |
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| | Candat, Adrien [VerfasserIn] |
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| | Scarpetta, Valentina [VerfasserIn] |
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| | Faucourt, Marion [VerfasserIn] |
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| | Weill, Solene [VerfasserIn] |
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| | Salio, Chiara [VerfasserIn] |
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| | D’Este, Elisa [VerfasserIn] |
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| | Meschkat, Martin [VerfasserIn] |
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| | Wurm, Christian A. [VerfasserIn] |
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| | Kneussel, Matthias [VerfasserIn] |
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| | Janke, Carsten [VerfasserIn] |
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| | Magiera, Maria M. [VerfasserIn] |
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| | Genovesio, Auguste [VerfasserIn] |
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| | Meunier, Alice [VerfasserIn] |
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| | Sassoè-Pognetto, Marco [VerfasserIn] |
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| | Brill, Monika S. [VerfasserIn] |
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| | Spassky, Nathalie [VerfasserIn] |
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| | Patrizi, Annarita [VerfasserIn] |
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| Titel: | Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage |
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| Verf.angabe: | Kim Hoa Ho, Adrien Candat, Valentina Scarpetta, Marion Faucourt, Solene Weill, Chiara Salio, Elisa D’Este, Martin Meschkat, Christian A. Wurm, Matthias Kneussel, Carsten Janke, Maria M. Magiera, Auguste Genovesio, Alice Meunier, Marco Sassoè-Pognetto, Monika S. Brill, Nathalie Spassky, and Annarita Patrizi |
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| E-Jahr: | 2023 |
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| Jahr: | 4 December 2023 |
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| Umfang: | 17 S. |
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| Fussnoten: | Online verfügbar 26 October 2023, Version des Artikels 4 December 2023 ; Gesehen am 12.04.2024 |
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| Titel Quelle: | Enthalten in: Developmental cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2001 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 58(2023), 23 vom: Dez., Seite 2641-2651, e1-e6 |
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| ISSN Quelle: | 1878-1551 |
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| Abstract: | Choroid plexuses (ChPs) produce cerebrospinal fluid and sense non-cell-autonomous stimuli to control the homeostasis of the central nervous system. They are mainly composed of epithelial multiciliated cells, whose development and function are still controversial. We have thus characterized the stepwise order of mammalian ChP epithelia cilia formation using a combination of super-resolution-microscopy approaches and mouse genetics. We show that ChP ciliated cells are built embryonically on a treadmill of spatiotemporally regulated events, starting with atypical centriole amplification and ending with the construction of nodal-like 9+0 cilia, characterized by both primary and motile features. ChP cilia undergo axoneme resorption at early postnatal stages through a microtubule destabilization process controlled by the microtubule-severing enzyme spastin and mitigated by polyglutamylation levels. Notably, this phenotype is preserved in humans, suggesting a conserved ciliary resorption mechanism in mammals. |
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| DOI: | doi:10.1016/j.devcel.2023.10.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.devcel.2023.10.003 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1534580723005233 |
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| | DOI: https://doi.org/10.1016/j.devcel.2023.10.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | aging |
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| | basal feet |
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| | cilia |
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| | development |
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| | electron microscopy |
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| | embryogenesis |
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| | human choroid plexus |
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| | multiciliogenesis |
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| | polyglutamylation |
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| | quantitative imaging |
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| K10plus-PPN: | 1885660316 |
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| Verknüpfungen: | → Zeitschrift |
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Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage / Ho, Kim Hoa [VerfasserIn]; 4 December 2023 (Online-Ressource)
