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| Verfasst von: | Illig, Maja [VerfasserIn]  |
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| | Jahnke, Kevin [VerfasserIn] |
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| | Weise, Lukas P. [VerfasserIn] |
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| | Scheffold, Marlene [VerfasserIn] |
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| | Mersdorf, Ulrike [VerfasserIn] |
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| | Drechsler, Hauke [VerfasserIn] |
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| | Zhang, Yixin [VerfasserIn] |
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| | Diez, Stefan [VerfasserIn] |
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| | Kierfeld, Jan [VerfasserIn] |
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| | Göpfrich, Kerstin [VerfasserIn] |
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| Titel: | Triggered contraction of self-assembled micron-scale DNA nanotube rings |
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| Verf.angabe: | Maja Illig, Kevin Jahnke, Lukas P. Weise, Marlene Scheffold, Ulrike Mersdorf, Hauke Drechsler, Yixin Zhang, Stefan Diez, Jan Kierfeld, Kerstin Göpfrich |
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| E-Jahr: | 2024 |
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| Jahr: | 14 March 2024 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 16.04.2024 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), Artikel-ID 2307, Seite 1-12 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction - without motor proteins - providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials. |
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| DOI: | doi:10.1038/s41467-024-46339-z |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-024-46339-z |
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| | Volltext: https://www.nature.com/articles/s41467-024-46339-z |
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| | DOI: https://doi.org/10.1038/s41467-024-46339-z |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biological physics |
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| | DNA nanomachines |
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| | Supramolecular assembly |
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| K10plus-PPN: | 1885924577 |
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| Verknüpfungen: | → Zeitschrift |
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Triggered contraction of self-assembled micron-scale DNA nanotube rings / Illig, Maja [VerfasserIn]; 14 March 2024 (Online-Ressource)
