Macular function testing in a German pedigree with North Carolina macular dystrophy

• Verfasst von: Rohrschneider, Klaus [VerfasserIn]
• Verfasst von: Blankenagel, Anita [VerfasserIn]
• Verfasst von: Kruse, Friedrich E. [VerfasserIn]
• Verfasst von: Fendrich, Thomas [VerfasserIn]
• Verfasst von: Völcker, Hans Eberhard [VerfasserIn]
• Titel: Macular function testing in a German pedigree with North Carolina macular dystrophy
• Verf.angabe: $hKlaus Rohrschneider, Anita Blankenagel, Friedrich E. Kruse, Thomas Fendrich, Hans E. Volcker
• Jahr: 1998
• Umfang: 7 S.
• Fussnoten: Gesehen am 16.04.2024
• Titel Quelle: Enthalten in: Retina
• Ort Quelle: Philadelphia, Pa. [u.a.] : Lippincott, Williams & Wilkins, 1981
• Jahr Quelle: 1998
• Band/Heft Quelle: 18(1998), 5, Seite 453-459
• ISSN Quelle: 1539-2864
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1885930496

Abstract

Background: Our purpose was to investigate central visual function in North Carolina macular dystrophy (MCDR1). A German family with genetically proven MCDR1 was followed for more than 20 years. Methods: In addition to routine clinical examinations, static and kinetic fundus perimetry was performed with the scanning laser ophthalmoscope. The center of fixation was determined.Results: Visual acuity was 0.6 or better in all but one eye of seven members of this family and did not markedly change during follow-up. Fundus examination confirmed that the fixation was at the nasal edge of the central scar in five affected eyes with reduced stability of fixation. One eye had a prominent gliotic membrane, and fixation was within this area. Conclusions: Patients had nearly normal visual acuity even though they presented with deep central scotomas and a shift of the center of fixation away from the fovea. Because MCDR1 has good long-term functional prognosis, there might be an early transdifferentiation of the new locus of fixation.