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Verfasst von:Zechmann, Christian [VerfasserIn]   i
 Simpfendörfer, Tobias [VerfasserIn]   i
 Giesel, Frederik L. [VerfasserIn]   i
 Zamecnik, Patrik [VerfasserIn]   i
 Thieke, Christian [VerfasserIn]   i
 Hielscher, Thomas [VerfasserIn]   i
 Meinzer, Hans-Peter [VerfasserIn]   i
 Delorme, Stefan [VerfasserIn]   i
Titel:Comparison of peripheral zone and central gland volume in patients undergoing intensity-modulated radiotherapy
Verf.angabe:Christian M. Zechmann, Tobias Simpfendörfer, Frederik L. Giesel, Patrik Zamecnik, Christian Thieke, Thomas Hielscher, Hans-Peter Meinzer, and Stefan Delorme
E-Jahr:2010
Jahr:September/October 2010
Umfang:7 S.
Fussnoten:Gesehen am 17.04.2024
Titel Quelle:Enthalten in: Journal of computer assisted tomography
Ort Quelle:Philadelphia, Pa. : Lippincott Williams & Wilkins, 1977
Jahr Quelle:2010
Band/Heft Quelle:34(2010), 5 vom: Sept./Okt., Seite 739-745
ISSN Quelle:1532-3145
Abstract:Background and Purpose: - The shrinking effect of androgen deprivation therapy (ADT) and radiotherapy (RT) on prostate gland volume is a known clinical finding. Until now, it is not known which part of the prostate shrinks more. We examined patients with and without ADT undergoing intensity-modulated RT (IMRT) and performed 3-dimensional measurements of the peripheral zone (PZ) and central gland (CG) with magnetic resonance imaging (MRI). - Methods and Materials: - Prostate gland volumes of PZ and CG between planning MRI and first available follow-up MRI were retrospectively determined in 44 patients with localized prostate carcinoma. A total of 24 patients had ADT with a median time interval of 5 months (range, 1.5-24 months). Median time interval between both MRI time points was 132 days (range, 104-224 days). Two observers performed PZ and CG delineation in consensus using planimetry. Volume changes over time were determined and compared. - Results: - Patients who had ADT showed smaller prostate volume in the first MRI (mean [SD], 32 [16.7] mL), which was still present after IMRT (28.1 [16.7] mL). Patients who had no ADT started with 44.6 (16.9) mL and showed 37.5 (13.9) mL after IMRT. Shrinking effect in PZ was significantly larger than in CG for all patients (−18.3% vs −6.3%, P < 0.05). - Conclusions: - Because, typically, most tumors are located in PZ and this area also shows the largest shrinkage effect after IMRT, this should be taken into account for planning purposes. Notably, there are only minor differences in the relative shrinking effects between patients with and without ADT, although they start with different volumes.
DOI:doi:10.1097/RCT.0b013e3181ebd14f
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/RCT.0b013e3181ebd14f
 Volltext: https://journals.lww.com/jcat/fulltext/2010/09000/comparison_of_peripheral_zone_and_central_gland.16.aspx
 DOI: https://doi.org/10.1097/RCT.0b013e3181ebd14f
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1886029784
Verknüpfungen:→ Zeitschrift

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