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| Verfasst von: | Fenioux, Charlotte [VerfasserIn]  |
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| | Abbar, Baptiste [VerfasserIn] |
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| | Boussouar, Samia [VerfasserIn] |
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| | Bretagne, Marie [VerfasserIn] |
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| | Power, John R. [VerfasserIn] |
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| | Moslehi, Javid J. [VerfasserIn] |
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| | Gougis, Paul [VerfasserIn] |
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| | Amelin, Damien [VerfasserIn] |
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| | Dechartres, Agnès [VerfasserIn] |
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| | Lehmann, Lorenz [VerfasserIn] |
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| | Courand, Pierre-Yves [VerfasserIn] |
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| | Cautela, Jennifer [VerfasserIn] |
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| | Alexandre, Joachim [VerfasserIn] |
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| | Procureur, Adrien [VerfasserIn] |
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| | Rozes, Antoine [VerfasserIn] |
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| | Leonard-Louis, Sarah [VerfasserIn] |
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| | Qin, Juan [VerfasserIn] |
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| | Cheynier, Rémi [VerfasserIn] |
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| | Charmeteau-De Muylder, Benedicte [VerfasserIn] |
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| | Redheuil, Alban [VerfasserIn] |
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| | Tubach, Florence [VerfasserIn] |
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| | Cadranel, Jacques [VerfasserIn] |
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| | Milon, Audrey [VerfasserIn] |
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| | Ederhy, Stéphane [VerfasserIn] |
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| | Similowski, Thomas [VerfasserIn] |
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| | Johnson, Douglas B. [VerfasserIn] |
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| | Pizzo, Ian [VerfasserIn] |
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| | Catalan, Toniemarie [VerfasserIn] |
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| | Benveniste, Olivier [VerfasserIn] |
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| | Hayek, Salim S. [VerfasserIn] |
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| | Allenbach, Yves [VerfasserIn] |
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| | Rosenzwajg, Michelle [VerfasserIn] |
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| | Dolladille, Charles [VerfasserIn] |
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| | Salem, Joe-Elie [VerfasserIn] |
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| Titel: | Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis |
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| Verf.angabe: | Charlotte Fenioux, Baptiste Abbar, Samia Boussouar, Marie Bretagne, John R. Power, Javid J. Moslehi, Paul Gougis, Damien Amelin, Agnès Dechartres, Lorenz H. Lehmann, Pierre-Yves Courand, Jennifer Cautela, Joachim Alexandre, Adrien Procureur, Antoine Rozes, Sarah Leonard-Louis, Juan Qin, Rémi Cheynier, Benedicte Charmeteau-De Muylder, Alban Redheuil, Florence Tubach, Jacques Cadranel, Audrey Milon, Stéphane Ederhy, Thomas Similowski, Douglas B. Johnson, Ian Pizzo, Toniemarie Catalan, Olivier Benveniste, Salim S. Hayek, Yves Allenbach, Michelle Rosenzwajg, Charles Dolladille & Joe-Elie Salem |
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| E-Jahr: | 2023 |
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| Jahr: | 26 October 2023 |
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| Umfang: | 21 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 17.04.2024 |
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| Titel Quelle: | Enthalten in: Nature medicine |
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| Ort Quelle: | New York, NY : Nature America Inc., 1995 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 29(2023), 12, Seite 3100-3110, [3], 1-7 |
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| ISSN Quelle: | 1546-170X |
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| Abstract: | Immune checkpoint inhibitors (ICI) have transformed the therapeutic landscape in oncology. However, ICI can induce uncommon life-threatening autoimmune T-cell-mediated myotoxicities, including myocarditis and myositis. The thymus plays a critical role in T cell maturation. Here we demonstrate that thymic alterations are associated with increased incidence and severity of ICI myotoxicities. First, using the international pharmacovigilance database VigiBase, the Assistance Publique Hôpitaux de Paris-Sorbonne University data warehouse (Paris, France) and a meta-analysis of clinical trials, we show that ICI treatment of thymic epithelial tumors (TET, and particularly thymoma) was more frequently associated with ICI myotoxicities than other ICI-treated cancers. Second, in an international ICI myocarditis registry, we established that myocarditis occurred earlier after ICI initiation in patients with TET (including active or prior history of TET) compared to other cancers and was more severe in terms of life-threatening arrythmias and concurrent myositis, leading to respiratory muscle failure and death. Lastly, we show that presence of anti-acetylcholine-receptor antibodies (a biological proxy of thymic-associated autoimmunity) was more prevalent in patients with ICI myocarditis than in ICI-treated control patients. Altogether, our results highlight that thymic alterations are associated with incidence and seriousness of ICI myotoxicities. Clinico-radio-biological workup evaluating the thymus may help in predicting ICI myotoxicities. |
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| DOI: | doi:10.1038/s41591-023-02591-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41591-023-02591-2 |
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| | Volltext: https://www.nature.com/articles/s41591-023-02591-2 |
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| | DOI: https://doi.org/10.1038/s41591-023-02591-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Errata: Fenioux, Charlotte: Author correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis |
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| Sach-SW: | Immunosurveillance |
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| | Translational research |
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| K10plus-PPN: | 1886089671 |
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| Verknüpfungen: | → Zeitschrift |
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Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis / Fenioux, Charlotte [VerfasserIn]; 26 October 2023 (Online-Ressource)
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