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Status: Bibliographieeintrag

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Verfasst von:Lu, Chang [VerfasserIn]   i
 Donners, Marjo M. P. C. [VerfasserIn]   i
 Karel, Joël [VerfasserIn]   i
 de Boer, Hetty [VerfasserIn]   i
 van Zonneveld, Anton Jan [VerfasserIn]   i
 den Ruijter, Hester [VerfasserIn]   i
 Jukema, J. Wouter [VerfasserIn]   i
 Kraaijeveld, Adriaan [VerfasserIn]   i
 Kuiper, Johan [VerfasserIn]   i
 Pasterkamp, Gerard [VerfasserIn]   i
 Cavill, Rachel [VerfasserIn]   i
 Perales-Patón, Javier [VerfasserIn]   i
 Ferrannini, Eleuterio [VerfasserIn]   i
 Goossens, Pieter [VerfasserIn]   i
 Biessen, Erik A. L. [VerfasserIn]   i
Titel:Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients
Verf.angabe:Chang Lu, Marjo M. P. C. Donners, Joël Karel, Hetty de Boer, Anton Jan van Zonneveld, Hester den Ruijter, J. Wouter Jukema, Adriaan Kraaijeveld, Johan Kuiper, Gerard Pasterkamp, Rachel Cavill, Javier Perales-Patón, Ele Ferrannini, Pieter Goossens, Erik A. L. Biessen
E-Jahr:2023
Jahr:November 23
Umfang:10 S.
Illustrationen:Illustrationen
Fussnoten:Online veröffentlicht: 2. April 2023 ; Gesehen am 22.04.2024
Titel Quelle:Enthalten in: Atherosclerosis
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1970
Jahr Quelle:2023
Band/Heft Quelle:384(2023), Artikel-ID 117123, Seite 1-10
ISSN Quelle:1879-1484
Abstract:Background and aims - This study aims to identify sex-specific transcriptional differences and signaling pathways in circulating monocytes contributing to cardiovascular disease. - Methods and results - We generated sex-biased gene expression signatures by comparing male versus female monocytes of coronary artery disease (CAD) patients (n = 450) from the Center for Translational Molecular Medicine-Circulating Cells Cohort. Gene set enrichment analysis demonstrated that monocytes from female CAD patients carry stronger chemotaxis and migratory signature than those from males. We then inferred cytokine signaling activities based on CytoSig database of 51 cytokine and growth factor regulation profiles. Monocytes from females feature a higher activation level of EGF, IFN1, VEGF, GM-CSF, and CD40L pathways, whereas IL-4, INS, and HMGB1 signaling was seen to be more activated in males. These sex differences were not observed in healthy subjects, as shown for an independent monocyte cohort of healthy subjects (GSE56034, n = 485). More pronounced GM-CSF signaling in monocytes of female CAD patients was confirmed by the significant enrichment of GM-CSF-activated monocyte signature in females. As we show these effects were not due to increased plasma levels of the corresponding ligands, sex-intrinsic differences in monocyte signaling regulation are suggested. Consistently, regulatory network analysis revealed jun-B as a shared transcription factor activated in all female-specific pathways except IFN1 but suppressed in male-activated IL-4. - Conclusions - We observed overt CAD-specific sex differences in monocyte transcriptional profiles and cytokine- or growth factor-induced responses, which provide insights into underlying mechanisms of sex differences in CVD.
DOI:doi:10.1016/j.atherosclerosis.2023.04.005
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.atherosclerosis.2023.04.005
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0021915023001600
 DOI: https://doi.org/10.1016/j.atherosclerosis.2023.04.005
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Coronary artery disease
 Monocyte
 Sex differences
 Signaling activities
 Transcription factor activities
K10plus-PPN:1886434603
Verknüpfungen:→ Zeitschrift

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