Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Kreißig, Sabine [VerfasserIn]  |
| Kutsche, Kerstin [VerfasserIn]  |
| Dear, Neil [VerfasserIn]  |
| Boehm, Thomas [VerfasserIn]  |
Titel: | Expression of peptides encoded by exons in cloned mammalian DNA |
Verf.angabe: | Sabine Kreissig, Kerstin Schüddekopf, Neil Dear, Thomas BoehM |
E-Jahr: | 1996 |
Jahr: | 01 November 1996 |
Umfang: | 2 S. |
Fussnoten: | Gesehen am 23.04.2024 |
Titel Quelle: | Enthalten in: Nucleic acids research |
Ort Quelle: | Oxford : Oxford Univ. Press, 1974 |
Jahr Quelle: | 1996 |
Band/Heft Quelle: | 24(1996), 21, Seite 4358-4359 |
ISSN Quelle: | 1362-4962 |
Abstract: | New synthetic approaches, such as combinatorial chemistry, provide a rich source of potential drug candidates. At the same time, the human genome initiative and other large-scale sequencing projects provide a large number of novel drug targets. However, the functional analysis of thousands of new genes remains a major challenge for the future. A systematic strategy for genome-wide functional analysis of genes could employ the fact that at least some modules in multi-domain proteins are encoded in individual exons. Exon amplification provides information about coding regions of most genes that is independent of their transcriptional status; exon amplification from entire mammalian genomes has been demonstrated. Here, we describe the development of an exon-trap system, λGEE (for genomic exon expression), that couples exon amplification with the expression of exon-encoded peptides. |
DOI: | doi:10.1093/nar/24.21.4358 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/nar/24.21.4358 |
| DOI: https://doi.org/10.1093/nar/24.21.4358 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1886564175 |
Verknüpfungen: | → Zeitschrift |
Expression of peptides encoded by exons in cloned mammalian DNA / Kreißig, Sabine [VerfasserIn]; 01 November 1996 (Online-Ressource)
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