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| Verfasst von: | Jablonska-Koch, Jadwiga [VerfasserIn]  |
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| | Rist, Malwina [VerfasserIn] |
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| | Spyra, Ilona [VerfasserIn] |
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| | Tengler, Luisa [VerfasserIn] |
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| | Domnich, Maksim [VerfasserIn] |
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| | Kansy, Benjamin [VerfasserIn] |
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| | Giebel, Bernd [VerfasserIn] |
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| | Thakur, Basant Kumar [VerfasserIn] |
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| | Rotter, Nicole [VerfasserIn] |
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| | Lang, Stephan [VerfasserIn] |
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| | Ludwig, Sonja [VerfasserIn] |
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| Titel: | Evaluation of immunoregulatory biomarkers on plasma small extracellular vesicles for disease progression and early therapeutic response in head and neck cancer |
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| Verf.angabe: | Jadwiga Jablonska, Malwina Rist, Ilona Spyra, Luisa Tengler, Maksim Domnich, Benjamin Kansy, Bernd Giebel, Basant Kumar Thakur, Nicole Rotter, Stephan Lang and Sonja Ludwig |
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| E-Jahr: | 2022 |
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| Jahr: | 5 March 2022 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 23.04.2024 |
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| Weitere Titel: | Titel des übergeordneten Special issue: Exosomes as mediators of immunosuppression in tumor and chronic inflammatory microenvironments |
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| Titel Quelle: | Enthalten in: Cells |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 11(2022), 5, Artikel-ID 902, Seite 1-14 |
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| ISSN Quelle: | 2073-4409 |
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| Abstract: | Head and Neck Cancers (HNCs) have highly immunosuppressive properties. Small extracellular vesicles (sEVs), including exosomes, nanosized mediators of intercellular communication in the blood, carry immunosuppressive proteins and effectively inhibit anti-tumor immune responses in HNCs. This study evaluates immunosuppressive markers on sEVs from 40 HNC patients at different disease stages and 3- and 6-month follow-up after surgery and/or chemoradiotherapy. As controls, sEVs from normal donors (NDs) are examined. Immunoregulatory surface markers on sEVs were detected as relative fluorescence intensity (RFI) using on-bead flow cytometry, and their expression levels were monitored in the early and late stages of HNC and during follow-up. In parallel, the sEV-mediated apoptosis of CD8+ Jurkat cells was assessed. Together with TGF-β1 and PD-L1 abundance, total sEV proteins are elevated with disease progression. In contrast, total sEV protein, including TGF-β1, PD-1 and PD-L1, decrease upon therapy response during follow-up. Overall survival analysis implies that high sEV PD-1/PD-L1 content is an unfavorable prognostic marker in HNC. Consistently, the sEV-mediated induction of apoptosis in CD8+ T cells correlates with the disease activity and therapy response. These findings indicate that a combination of immunoregulatory marker profiles should be preferred over a single marker to monitor disease progression and therapy response in HNC. |
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| DOI: | doi:10.3390/cells11050902 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cells11050902 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2073-4409/11/5/902 |
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| | DOI: https://doi.org/10.3390/cells11050902 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | biomarkers |
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| | exosomes |
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| | immunoregulation |
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| | small extracellular vesicles (sEVs) |
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| | therapy response |
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| K10plus-PPN: | 1886564817 |
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| Verknüpfungen: | → Zeitschrift |
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Evaluation of immunoregulatory biomarkers on plasma small extracellular vesicles for disease progression and early therapeutic response in head and neck cancer / Jablonska-Koch, Jadwiga [VerfasserIn]; 5 March 2022 (Online-Ressource)
