Association between EGF, TGF-β1, TNF-α gene polymorphisms and cancer of the pancreatic head

• Verfasst von: Wu, Guo-Yang [VerfasserIn]
• Verfasst von: Lu, Qingjun [VerfasserIn]
• Verfasst von: Hasenberg, Till [VerfasserIn]
• Verfasst von: Niedergethmann, Marco [VerfasserIn]
• Verfasst von: Post, Stefan [VerfasserIn]
• Verfasst von: Sturm, Jörg [VerfasserIn]
• Verfasst von: Keese, Michael [VerfasserIn]
• Titel: Association between EGF, TGF-β1, TNF-α gene polymorphisms and cancer of the pancreatic head
• Verf.angabe: Guo-Yang Wu, Qingjun Lu, Till Hasenberg, Marco Niedergethmann, Stefan Post, Jörg W. Sturm and Michael Keese
• E-Jahr: 2010
• Jahr: December 2010
• Umfang: 5 S.
• Fussnoten: Gesehen am 30.04.2024
• Titel Quelle: Enthalten in: Anticancer research
• Ort Quelle: Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004
• Jahr Quelle: 2010
• Band/Heft Quelle: 30(2010), 12 vom: Dez., Seite 5257-5261
• ISSN Quelle: 1791-7530
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: EGF
• Sach-SW: gene polymorphism
• Sach-SW: growth factors
• Sach-SW: Pancreatic cancer
• Sach-SW: TGF-β1
• Sach-SW: TNF-α
• K10plus-PPN: 188743366X

Abstract

Background: To date, EGF 61*A/G, TGF-β1 -509*T/C and TNF-α -308*A/G gene polymorphisms have been not been analysed in pancreatic carcinoma. This study investigated the frequency of these gene polymorphisms among patients with cancer of the pancreatic head. Patients and Methods: A total of 73 pancreatic head cancer patients and 117 cancer-free healthy people were recruited at the Surgical Department of the University Hospital Mannheim. Genomic DNA was isolated from peripheral blood and gene polymorphisms were analysed by PCR-RFLP. Results: The distribution of EGF 61*G/G homozygotes among pancreatic head cancer patients was more frequent than that in the control group (24.7% vs 11.1%, odds ratio (OR)=2.618, 95% confidence interval (CI)=1.195-5.738). In addition, the frequency of the G allele in the pancreatic head cancer patient group was also higher than that in the control group (45.9% vs. 33.3%, OR=1.696, 95% CI=1.110-2.592). No difference was found for the TGF-β1 -509 and TNF-α -308 genotypes among pancreatic head cancer patients and healthy controls. Conclusion: The frequencies of the EGF 61*G/G genotype and G allele are significantly increased among patients with pancreatic head cancer. TGF-β1-509*T/C and TNF-α -308*A/G gene polymorphisms are not related to this cancer entity.