Clinical impact of GB-C virus in haemodialysis patients

• Verfasst von: Kallinowski, Birgit [VerfasserIn]
• Verfasst von: Ahmadi, Rezvan [VerfasserIn]
• Verfasst von: Seipp, Stefanie [VerfasserIn]
• Verfasst von: Bommer, Jürgen [VerfasserIn]
• Verfasst von: Stremmel, Wolfgang [VerfasserIn]
• Titel: Clinical impact of GB-C virus in haemodialysis patients
• Verf.angabe: Birgit Kallinowski, Rezvan Ahmadi, Stefani Seipp, Jürgen Bommer, Wolfgang Stremmel
• E-Jahr: 1998
• Jahr: 01 January 1998
• Umfang: 6 S.
• Fussnoten: Gesehen am 06.05.2024
• Titel Quelle: Enthalten in: Nephrology, dialysis, transplantation
• Ort Quelle: Oxford : Oxford Univ. Press, 1986
• Jahr Quelle: 1998
• Band/Heft Quelle: 13(1998), 1, Seite 93-98
• ISSN Quelle: 1460-2385
• DOI: doi:10.1093/ndt/13.1.93
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1887906614

Abstract

Background. Haemodialysis patients run a high risk of acquiring viral hepatitis B (HBV) or C (HCV) infection. Recently a new parenterally transmittable RNA virus, designated GBV-C, was isolated.Methods. We therefore screened 266 patients on maintenance dialysis and 358 blood donors as a control group for GBV-C by nested PCR and correlated the data with AST, ALT, duration of dialysis, transfusions, renal transplants and coinfections with HBV and HCV.Results. The prevalence of GBV-C among haemodialysis patients was 7.9%, and 3.6% among blood donors. Neither duration of dialysis nor number of blood transfusions were associated with GBV-C infection, whereas GBV-C-positive patients were significantly more often transplanted than GBV-C-negative individuals. Transaminases of GBV-C-positive individuals remained within normal limits in all haemodialysis patients and normal in all infected blood donors. Coinfections of GBV-C with HBV and HCV were only present in 0.7% and 1% respectively.Conclusions. We conclude that GBV-C virus infection is frequent among haemodialysis patients. Transaminases cannot serve as surrogate markers, and parenteral as well as community-acquired infection seems to be possible.