| Online-Ressource |
Verfasst von: | Weinland, Christian [VerfasserIn]  |
| Mühle, Christiane [VerfasserIn]  |
| von Zimmermann, Claudia [VerfasserIn]  |
| Kornhuber, Johannes [VerfasserIn]  |
| Lenz, Bernd [VerfasserIn]  |
Titel: | Sulphated dehydroepiandrosterone serum levels are reduced in women with alcohol use disorder and correlate negatively with craving |
Titelzusatz: | a sex-separated cross-sectional and longitudinal study |
Verf.angabe: | Christian Weinland, Christiane Mühle, Claudia von Zimmermann, Johannes Kornhuber, Bernd Lenz |
E-Jahr: | 2022 |
Jahr: | March 2022 |
Umfang: | 11 S. |
Fussnoten: | Erstmals veröffentlicht: 13. Januar 2022 ; Gesehen am 06.05.2024 |
Titel Quelle: | Enthalten in: Addiction biology |
Ort Quelle: | Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996 |
Jahr Quelle: | 2022 |
Band/Heft Quelle: | 27(2022), 2 vom: März, Artikel-ID e13135, Seite 1-11 |
ISSN Quelle: | 1369-1600 |
Abstract: | Previous studies have established a role of sex hormones in alcohol use disorder (AUD).Only few clinical investigations with low numbers of patients with AUD have focused on the sulphated form of dehydroepiandrosterone (DHEA-S), despite its function as a neuromodulating sex steroid on receptors in the central nervous system (γ-aminobutyric acid type A, N-methyl-D-aspartate, sigma-1 receptors). DHEA-S serum levels were compared between 200 inpatients with AUD (44% women) admitted for withdrawal treatment and 240 healthy controls (45% women) and analysed longitudinally in patients from early abstinence (baseline) to a median of 5 days later. We also correlated DHEA-S levels with craving, liver enzyme activities, and prospective alcohol-related readmissions during a 24-month follow-up. DHEA-S concentrations were lower in female patients than in female healthy controls during baseline (70%) and decreased from baseline to follow-up in the female and male patients groups (down to: women, 92%; men, 76%). Baseline DHEA-S concentrations correlated with the total and obsessive subscales of the Obsessive-Compulsive Drinking Scale and with maximum visual analogue scale craving scores in female patients (Rho ≤ −0.240) and gamma-glutamyl transferase activity in female (Rho = −0.292) and male (Rho = −0.391) patients. DHEA-S did not significantly predict outcome. We found interactions with smoking behaviour and age. This is the first study based on large cohorts of inpatients with AUD undergoing a qualified detoxification treatment to provide sex-separated evidence for associations of DHEA-S serum concentrations with AUD and related phenotypes. The results stimulate further investigations whether DHEA-S directly influences alcohol craving building a basis to develop sex-sensitive prevention and treatment strategies. |
DOI: | doi:10.1111/adb.13135 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1111/adb.13135 |
| kostenfrei: Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/adb.13135 |
| DOI: https://doi.org/10.1111/adb.13135 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | AUD |
| craving |
| DHEA -S |
| relapse |
| sex hormones |
K10plus-PPN: | 188791580X |
Verknüpfungen: | → Zeitschrift |
Sulphated dehydroepiandrosterone serum levels are reduced in women with alcohol use disorder and correlate negatively with craving / Weinland, Christian [VerfasserIn]; March 2022 (Online-Ressource)