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Verfasst von:Weinland, Christian [VerfasserIn]   i
 Mühle, Christiane [VerfasserIn]   i
 von Zimmermann, Claudia [VerfasserIn]   i
 Kornhuber, Johannes [VerfasserIn]   i
 Lenz, Bernd [VerfasserIn]   i
Titel:Sulphated dehydroepiandrosterone serum levels are reduced in women with alcohol use disorder and correlate negatively with craving
Titelzusatz:a sex-separated cross-sectional and longitudinal study
Verf.angabe:Christian Weinland, Christiane Mühle, Claudia von Zimmermann, Johannes Kornhuber, Bernd Lenz
E-Jahr:2022
Jahr:March 2022
Umfang:11 S.
Fussnoten:Erstmals veröffentlicht: 13. Januar 2022 ; Gesehen am 06.05.2024
Titel Quelle:Enthalten in: Addiction biology
Ort Quelle:Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996
Jahr Quelle:2022
Band/Heft Quelle:27(2022), 2 vom: März, Artikel-ID e13135, Seite 1-11
ISSN Quelle:1369-1600
Abstract:Previous studies have established a role of sex hormones in alcohol use disorder (AUD).Only few clinical investigations with low numbers of patients with AUD have focused on the sulphated form of dehydroepiandrosterone (DHEA-S), despite its function as a neuromodulating sex steroid on receptors in the central nervous system (γ-aminobutyric acid type A, N-methyl-D-aspartate, sigma-1 receptors). DHEA-S serum levels were compared between 200 inpatients with AUD (44% women) admitted for withdrawal treatment and 240 healthy controls (45% women) and analysed longitudinally in patients from early abstinence (baseline) to a median of 5 days later. We also correlated DHEA-S levels with craving, liver enzyme activities, and prospective alcohol-related readmissions during a 24-month follow-up. DHEA-S concentrations were lower in female patients than in female healthy controls during baseline (70%) and decreased from baseline to follow-up in the female and male patients groups (down to: women, 92%; men, 76%). Baseline DHEA-S concentrations correlated with the total and obsessive subscales of the Obsessive-Compulsive Drinking Scale and with maximum visual analogue scale craving scores in female patients (Rho ≤ −0.240) and gamma-glutamyl transferase activity in female (Rho = −0.292) and male (Rho = −0.391) patients. DHEA-S did not significantly predict outcome. We found interactions with smoking behaviour and age. This is the first study based on large cohorts of inpatients with AUD undergoing a qualified detoxification treatment to provide sex-separated evidence for associations of DHEA-S serum concentrations with AUD and related phenotypes. The results stimulate further investigations whether DHEA-S directly influences alcohol craving building a basis to develop sex-sensitive prevention and treatment strategies.
DOI:doi:10.1111/adb.13135
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1111/adb.13135
 kostenfrei: Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/adb.13135
 DOI: https://doi.org/10.1111/adb.13135
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:AUD
 craving
 DHEA -S
 relapse
 sex hormones
K10plus-PPN:188791580X
Verknüpfungen:→ Zeitschrift

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