Sulphated dehydroepiandrosterone serum levels are reduced in women with alcohol use disorder and correlate negatively with craving

• Verfasst von: Weinland, Christian [VerfasserIn]
• Verfasst von: Mühle, Christiane [VerfasserIn]
• Verfasst von: von Zimmermann, Claudia [VerfasserIn]
• Verfasst von: Kornhuber, Johannes [VerfasserIn]
• Verfasst von: Lenz, Bernd [VerfasserIn]
• Titel: Sulphated dehydroepiandrosterone serum levels are reduced in women with alcohol use disorder and correlate negatively with craving
• Titelzusatz: a sex-separated cross-sectional and longitudinal study
• Verf.angabe: Christian Weinland, Christiane Mühle, Claudia von Zimmermann, Johannes Kornhuber, Bernd Lenz
• E-Jahr: 2022
• Jahr: March 2022
• Umfang: 11 S.
• Fussnoten: Erstmals veröffentlicht: 13. Januar 2022 ; Gesehen am 06.05.2024
• Titel Quelle: Enthalten in: Addiction biology
• Ort Quelle: Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996
• Jahr Quelle: 2022
• Band/Heft Quelle: 27(2022), 2 vom: März, Artikel-ID e13135, Seite 1-11
• ISSN Quelle: 1369-1600
• DOI: doi:10.1111/adb.13135
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: AUD
• Sach-SW: craving
• Sach-SW: DHEA -S
• Sach-SW: relapse
• Sach-SW: sex hormones
• K10plus-PPN: 188791580X

Abstract

Previous studies have established a role of sex hormones in alcohol use disorder (AUD).Only few clinical investigations with low numbers of patients with AUD have focused on the sulphated form of dehydroepiandrosterone (DHEA-S), despite its function as a neuromodulating sex steroid on receptors in the central nervous system (γ-aminobutyric acid type A, N-methyl-D-aspartate, sigma-1 receptors). DHEA-S serum levels were compared between 200 inpatients with AUD (44% women) admitted for withdrawal treatment and 240 healthy controls (45% women) and analysed longitudinally in patients from early abstinence (baseline) to a median of 5 days later. We also correlated DHEA-S levels with craving, liver enzyme activities, and prospective alcohol-related readmissions during a 24-month follow-up. DHEA-S concentrations were lower in female patients than in female healthy controls during baseline (70%) and decreased from baseline to follow-up in the female and male patients groups (down to: women, 92%; men, 76%). Baseline DHEA-S concentrations correlated with the total and obsessive subscales of the Obsessive-Compulsive Drinking Scale and with maximum visual analogue scale craving scores in female patients (Rho ≤ −0.240) and gamma-glutamyl transferase activity in female (Rho = −0.292) and male (Rho = −0.391) patients. DHEA-S did not significantly predict outcome. We found interactions with smoking behaviour and age. This is the first study based on large cohorts of inpatients with AUD undergoing a qualified detoxification treatment to provide sex-separated evidence for associations of DHEA-S serum concentrations with AUD and related phenotypes. The results stimulate further investigations whether DHEA-S directly influences alcohol craving building a basis to develop sex-sensitive prevention and treatment strategies.