Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Zhu, Yu-Ting [VerfasserIn]  |
|---|
| | Wan, Cheng [VerfasserIn] |
|---|
| | Lin, Jihong [VerfasserIn] |
|---|
| | Hammes, Hans-Peter [VerfasserIn] |
|---|
| | Zhang, Chun [VerfasserIn] |
|---|
| Titel: | Mitochondrial oxidative stress and cell death in podocytopathies |
|---|
| Verf.angabe: | Yu-Ting Zhu, Cheng Wan, Ji-Hong Lin, Hans-Peter Hammes and Chun Zhang |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | 4 March 2022 |
|---|
| Umfang: | 19 S. |
|---|
| Fussnoten: | Gesehen am 07.05.2024 |
|---|
| Weitere Titel: | Titel des übergeordneten Special issue: Redox imbalance and mitochondrial abnormalities in kidney disease |
|---|
| Titel Quelle: | Enthalten in: Biomolecules |
|---|
| Ort Quelle: | Basel : MDPI, 2011 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 12(2022), 3, Artikel-ID 403, Seite 1-19 |
|---|
| ISSN Quelle: | 2218-273X |
|---|
| Abstract: | Podocytopathies are kidney diseases that are driven by podocyte injury with proteinuria and proteinuria-related symptoms as the main clinical presentations. Albeit podocytopathies are the major contributors to end-stage kidney disease, the underlying molecular mechanisms of podocyte injury remain to be elucidated. Mitochondrial oxidative stress is associated with kidney diseases, and increasing evidence suggests that oxidative stress plays a vital role in the pathogenesis of podocytopathies. Accumulating evidence has placed mitochondrial oxidative stress in the focus of cell death research. Excessive generated reactive oxygen species over antioxidant defense under pathological conditions lead to oxidative damage to cellular components and regulate cell death in the podocyte. Conversely, exogenous antioxidants can protect podocyte from cell death. This review provides an overview of the role of mitochondrial oxidative stress in podocytopathies and discusses its role in the cell death of the podocyte, aiming to identify the novel targets to improve the treatment of patients with podocytopathies. |
|---|
| DOI: | doi:10.3390/biom12030403 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/biom12030403 |
|---|
| | kostenfrei: Volltext: https://www.mdpi.com/2218-273X/12/3/403 |
|---|
| | DOI: https://doi.org/10.3390/biom12030403 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | antioxidant defense |
|---|
| | cell death |
|---|
| | mitochondrial oxidative stress |
|---|
| | podocytopathies |
|---|
| | reactive oxygen species (ROS) |
|---|
| K10plus-PPN: | 1887969144 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Mitochondrial oxidative stress and cell death in podocytopathies / Zhu, Yu-Ting [VerfasserIn]; 4 March 2022 (Online-Ressource)
69211742
