Tumor-reactive T helper cells in the context of vaccination against glioma

• Verfasst von: Zhao, Binghao [VerfasserIn]
• Verfasst von: Kilian, Michael [VerfasserIn]
• Verfasst von: Bunse, Theresa [VerfasserIn]
• Verfasst von: Platten, Michael [VerfasserIn]
• Verfasst von: Bunse, Lukas [VerfasserIn]
• Titel: Tumor-reactive T helper cells in the context of vaccination against glioma
• Verf.angabe: Binghao Zhao, Michael Kilian, Theresa Bunse, Michael Platten and Lukas Bunse
• E-Jahr: 2023
• Jahr: 13 November 2023
• Umfang: 6 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 19. Oktober 2023, Artikelversion: 13. November 2023 ; Gesehen am 07.05.2024
• Titel Quelle: Enthalten in: Cancer cell
• Ort Quelle: Cambridge, Mass. : Cell Press, 2002
• Jahr Quelle: 2023
• Band/Heft Quelle: 41(2023), 11 vom: Nov., Seite 1829-1834
• ISSN Quelle: 1878-3686
• DOI: doi:10.1016/j.ccell.2023.09.013
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1887982744

Abstract

With the advances in immunogenomics, the majority of tumor-specific antigens were found to be recognized by T helper cells (THCs). This observation led to the development of long epitope vaccines in various cancers. Mechanistically, we are still gaining a deeper understanding of the mode of action of THCs as precision antitumor agonists. Here, we discuss the specific cellular mechanisms of THC functions in glioma immunology and contextualize current advances in anti-glioma vaccination exploiting THCs.