Potential transfer of endotoxin across high-flux polysulfone membranes.

• Verfasst von: Bommer, Jürgen [VerfasserIn]
• Verfasst von: Becker, Klaus-Peter [VerfasserIn]
• Verfasst von: Urbaschek, Renate [VerfasserIn]
• Titel: Potential transfer of endotoxin across high-flux polysulfone membranes.
• Verf.angabe: J. Bommer, K.P. Becker, R. Urbaschek
• E-Jahr: 1996
• Jahr: June 1996
• Umfang: 6 S.
• Fussnoten: Gesehen am 08.05.2024
• Titel Quelle: Enthalten in: American Society of NephrologyJournal of the American Society of Nephrology
• Ort Quelle: Washington, DC : American Society of Nephrology, 1990
• Jahr Quelle: 1996
• Band/Heft Quelle: 7(1996), 6, Seite 883-888
• ISSN Quelle: 1533-3450
• DOI: doi:10.1681/ASN.V76883
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1888126930

Abstract

It has been postulated that synthetic membranes, such as polysulfone membranes, are rather impermeable for endotoxin or endotoxin fragments and can be used for sterile filtration of dialysate. It has never been investigated, however, whether endotoxin permeability may be different in commercially available polysulfone membranes. In vitro, we found a significantly different permeability for endotoxin in two standard dialyzers and one test dialyzer with high-flux polysulfone membranes. In contrast to the F-60 dialyzer with a very low permeability for endotoxin, a stepwise increasing load of endotoxin concentration in the dialysate compartment of the PN 1913 test dialyzer and Primus 1350 polysulfone dialyzer was followed by a stepwise increase of endotoxin in the blood compartment. A significant transfer across the membranes was found when the endotoxin concentration in the dialysate compartment was > 10 ng/mL in the PN 1913 and > 0.5 ng/mL in the Primus 1350. In the latter, about 0.5% of the endotoxin concentration of the dialysate compartment was found in the blood compartment. The data suggest that manufacturers have to evaluate the performance and other properties of their synthetic membranes in detail.