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| Verfasst von: | Groh, Janos [VerfasserIn]  |
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| | Abdelwahab, Tassnim [VerfasserIn] |
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| | Kattimani, Yogita [VerfasserIn] |
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| | Hörner, Michaela [VerfasserIn] |
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| | Loserth, Silke [VerfasserIn] |
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| | Gudi, Viktoria [VerfasserIn] |
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| | Adalbert, Robert [VerfasserIn] |
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| | Imdahl, Fabian [VerfasserIn] |
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| | Saliba, Antoine-Emmanuel [VerfasserIn] |
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| | Coleman, Michael [VerfasserIn] |
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| | Stangel, Martin [VerfasserIn] |
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| | Simons, Mikael [VerfasserIn] |
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| | Martini, Rudolf [VerfasserIn] |
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| Titel: | Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects |
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| Verf.angabe: | Janos Groh, Tassnim Abdelwahab, Yogita Kattimani, Michaela Hörner, Silke Loserth, Viktoria Gudi, Robert Adalbert, Fabian Imdahl, Antoine-Emmanuel Saliba, Michael Coleman, Martin Stangel, Mikael Simons & Rudolf Martini |
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| E-Jahr: | 2023 |
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| Jahr: | 30 October 2023 |
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| Umfang: | 21 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Veröffentlicht: 30. Oktober 2023 ; Gesehen am 13.05.2024 ; Im Titel ist das Pluszeichen hochgestellt |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 14(2023), Artikel-ID 6911, Seite 1-21 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal damage. Here we study mice with distinct defects in the proteolipid protein 1 gene that develop axonal damage which is driven by cytotoxic T cells targeting myelinating oligodendrocytes. We show that persistent ensheathment with perturbed myelin poses a risk for axon degeneration, neuron loss, and behavioral decline. We demonstrate that CD8+ T cell-driven axonal damage is less likely to progress towards degeneration when axons are efficiently demyelinated by activated microglia. Mechanistically, we show that cytotoxic T cell effector molecules induce cytoskeletal alterations within myelinating glia and aberrant actomyosin constriction of axons at paranodal domains. Our study identifies detrimental axon-glia-immune interactions which promote neurodegeneration and possible therapeutic targets for disorders associated with myelin defects and neuroinflammation. |
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| DOI: | doi:10.1038/s41467-023-42570-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-023-42570-2 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-023-42570-2 |
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| | DOI: https://doi.org/10.1038/s41467-023-42570-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Diseases of the nervous system |
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| | Myelin biology and repair |
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| | Neuroimmunology |
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| K10plus-PPN: | 1888342560 |
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| Verknüpfungen: | → Zeitschrift |
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Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects / Groh, Janos [VerfasserIn]; 30 October 2023 (Online-Ressource)
